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Somatic and psychological factors related to the body mass index of patients with anorexia nervosa

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Abstract

Objective: The aim of this study was to examine somatic and psychological factors related to the body mass index (BMI) of anorexia nervosa (AN) patients. Method: The analysis was of 24 hospitalized AN patients from the day after admission to the 4th day. The somatic factors analyzed were duration of AN, daily food intake, eating regulatory substances in blood (acylated ghrelin, desacyl ghrelin, leptin), serum cortisol, insulin and estimated creatinine clearance (CCr). The psychological factors analyzed were depression, anxiety, Eating Disorder Inventory (EDI), and hunger/fullness feeling. Measurement of BMI and collection of blood samples were done on the morning after hospitalization. Statistical analysis was by multiple linear regression analysis. Results: BMI showed a reverse correlation with desacyl ghrelin (β=-0.486, p=0.015) and maturity fears (β=-0.375, p=0.046), but was not associated with any other factor by multiple regression analysis. Conclusion: The results suggest that desacyl ghrelin and maturity fears play important roles in the prolonged malnutrition state seen in AN patients.

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References

  1. Kishi T., Elmquist J.K.: Body weight is regulated by the brain: a link between feeding and emotion. Mol. Psychiatry, 10, 132–146, 2005.

    Article  PubMed  CAS  Google Scholar 

  2. Klok M.D., Jakobsdottir S., Drent M.L.: The role of leptin and ghrelin in the regulation of food intake and body weight in humans: a review. Obes. Rev., 8, 21–34, 2007.

    Article  PubMed  CAS  Google Scholar 

  3. Zhang Y., Proenca R., Maffei M., Barone M., Leopold L., Friedman J.M.: Positional cloning of the mouse gene and its human homolog. Nature, 372, 425–432, 1994.

    Article  PubMed  CAS  Google Scholar 

  4. Kojima M., Hosoda H., Date Y., Nakazato H., Kangawa K.: Ghrelin is a growth-hormone-releasing acylated peptide from the stomach. Nature, 402, 656–660, 1999.

    Article  PubMed  CAS  Google Scholar 

  5. Grinspoon S., Gulick T., Askari H., Landt M., Lee K., Anderson E., Ma Z., Vignati L., Bowsher R., Herzog D., Klibanski A.: Serum leptin levels in women with anorexia nervosa. J. Clin. Endocrinol. Metab., 81, 3861–3863, 1996.

    Article  PubMed  CAS  Google Scholar 

  6. Tolle V., Kadem M., Bluet-Pajot M.T., Frere D., Foulon C., Bossu C., Dardennes R., Mounier C., Zizzari P., Lang F., Epelbaum J., Estour B.: Balance in ghrelin and leptin plasma levels in anorexia nervosa patients and constitutionally thin women. J. Clin. Endocrinol. Metab., 88, 109–116, 2003.

    Article  PubMed  CAS  Google Scholar 

  7. Tanaka M., Naruo T., Yasuhara D., Takebe Y., Nagai N., Shiiya T., Nakazato M., Matsukura S., Nozoe S.: Fasting plasma ghrelin levels in subtypes of anorexia nervosa. Psychoneuroendocrinology, 28, 829–835, 2003.

    Article  PubMed  CAS  Google Scholar 

  8. Hebebrand J., Muller T.D., Holtkamp K., Herpertz-Dahlmann B.: The role of leptin in anorexia nervosa: clinical implications Mol. Psychiatry, 12, 23–35, 2007.

    CAS  Google Scholar 

  9. Misra M., Miller K.K., Kuo K., Griffin K., Stewart V., Hunter E., Herzog D.B., Klibanski A.: Secretory dynamics of ghrelin in adolescent girls with anorexia nervosa and healthy adolescents. Am. J. Physiol. Endocrinol. Metab., 289, E347–E356, 2005.

    Article  PubMed  CAS  Google Scholar 

  10. Misra M., Miller K.K., Kuo K., Griffin K., Stewart V., Hunter E., Herzog D.B., Klibanski A.: Secretory dynamics of leptin in adolescent girls with anorexia nervosa and healthy adolescents. Am. J. Physiol. Endocrinol. Metab., 289, E373–E381, 2005.

    Article  PubMed  CAS  Google Scholar 

  11. Hosoda H., Kojima M., Matsuo H., Kangawa K.: Ghrelin and des-acyl ghrelin: two major forms of rat ghrelin peptide in gastrointestinal tissue. Biochem. Biophys. Res. Commun., 279, 909–913, 2000.

    Article  PubMed  CAS  Google Scholar 

  12. Nedvidkova J., Krykorkova I.: Loss of meal-induced decrease in plasma ghrelin levels in patients with anorexia nervosa. J. Clin. Endocrinol. Metab., 88, 1678–1682, 2003.

    Article  PubMed  CAS  Google Scholar 

  13. Hotta M., Ohwada R., Katakami H., Shibasaki T., Hizuka N., Takano K.: Plasma levels of intact and degraded ghrelin and their responses to glucose infusion in anorexia nervosa. J. Clin. Endocrinol. Metab., 89, 5707–5712, 2004.

    Article  PubMed  CAS  Google Scholar 

  14. American Psychiatric Association. Diagnostic and Statistical Manual of Mental Disorders, 4th Ed. Washington, DC, American Psychiatric Association, 1994.

    Google Scholar 

  15. First M.B., Gibbon M., Spitzer R.L., Williams J.B.W.: User’s Guide for the Structured Clinical Interview for DSM-IV AXIS I Disorders: Research Version. New York, Biometrics Research Department, Columbia University, 1996.

    Google Scholar 

  16. Garner D.M., Vitousek K.M., Pike K.M.: Cognitivebehavioral therapy for anorexia nervosa. In: Garner D.M., Garfinkel P.E. (eds.), Handbook of treatment for eating disorders, 2nd Ed. New York, Guilford, 1997, pp. 94–141.

    Google Scholar 

  17. Cockcroft D.W., Gault M.H.: Prediction of creatinine clearance from serum creatinine. Nephron, 16, 31–41, 1976.

    Article  PubMed  CAS  Google Scholar 

  18. Garner D.M., Olmsted M.P.: Development and validation of a multidimensional eating disorder inventory for anorexia nervosa and bulimia. Int. J. Eat. Disord., 2, 15–34, 1983.

    Article  Google Scholar 

  19. Zung W.W.K.: The depression status inventory: an adjunct to the Self-Rating Depression Scale. J. Clin. Psychol., 28, 539–543, 1972.

    Article  PubMed  CAS  Google Scholar 

  20. Spielberger C.D., Gorsuch R.L., Lushene R., Vagg P.R., Jacob G.A.: Manual for the State Trait Anxiety Inventory (Form Y). Palo Alto, CA, Consulting Psychology Press, 1983.

    Google Scholar 

  21. Stock S., Leichner P., Wong A., Ghatei M.A., Kieffer T.J., Bloom S.R., Chanoine J.P.: Ghrelin, peptide YY, glucose-dependent insulinotropic polypeptides, and hunger responses to a mixed meal in anorexic, obese, and control female adolescents. J. Clin. Endocrinol. Metab., 90: 2161–2168, 2005.

    Article  PubMed  CAS  Google Scholar 

  22. Yoshimoto A., Mori K., Sugawara A., Mukoyama M., Yahata K., Suganami T., Takaya K., Hosoda H., Kojima M., Kangawa K., Nakao K.: Plasma ghrelin and desacyl ghrelin concentrations in renal failure. J. Am. Soc. Nephrol., 13, 2748–2752, 2002.

    Article  PubMed  CAS  Google Scholar 

  23. Asakawa A., Inui A., Fujimiya M., Sakamaki R., Shinfuku N., Ueta Y., Meguid M.M., Kasuga M.: Stomach regulates energy balance via acylated ghrelin and desacyl ghrelin. Gut, 54, 18–24, 2005.

    Article  PubMed  CAS  Google Scholar 

  24. Chen C.-Y., Chao Y., Chang F.Y., Chien E.J., Lee S.D., Doong M.L.: Intracisternal desacyl ghrelin inhibits food intake and non-nutrient gastric emptying in conscious rats. Int. J. Mol. Med., 16, 695–699, 2005.

    PubMed  CAS  Google Scholar 

  25. Tschop M., Smiley D.L., Heiman M.L.: Ghrelin induces adiposity in rodents. Nature, 407, 908–913, 2000.

    Article  PubMed  CAS  Google Scholar 

  26. Crisp A.H.: Anorexia nervosa as flight from growth: Assessment and treatment based on the model. Cognitive-behavioral Therapy for Anorexia Nervosa. In: Garner D.M., Garfinkel P.E. (eds), Handbook of treatment for eating disorders, 2nd Ed. New York, Guilford, 1997, pp. 248–268.

    Google Scholar 

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Authors and Affiliations

  1. Department of Psychosomatic Medicine, Graduate School of Medical Science, Kyushu University, 3-1-1 Higashi-ku, Fukuoka, 812-8582, Japan

    K. Kawai M.D., Ph.D., S. Yamashita, M. Gondo, C. Morita, C. Arimura, T. Nozaki, M. Takii & C. Kubo

  2. Institute for Clinical Research, National Kyushu Cancer Center, Fukuoka, Japan

    T. Yamanaka

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  1. K. Kawai M.D., Ph.D.
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  2. T. Yamanaka
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  3. S. Yamashita
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  4. M. Gondo
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  5. C. Morita
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  6. C. Arimura
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  7. T. Nozaki
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  8. M. Takii
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  9. C. Kubo
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Correspondence to K. Kawai M.D., Ph.D..

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Kawai, K., Yamanaka, T., Yamashita, S. et al. Somatic and psychological factors related to the body mass index of patients with anorexia nervosa. Eat Weight Disord 13, 198–204 (2008). https://doi.org/10.1007/BF03327507

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  • DOI: https://doi.org/10.1007/BF03327507

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