Skip to main content
SpringerLink
Log in

In Vivo Effect of Cimetidine and Roxatidine on the Allogeneic Graft-Versus-Host Reaction

  • Short Communication
  • Published:
Drug Investigation Aims and scope Submit manuscript

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

References

  • Avella J, Madsen JE, Binder HJ, Askenase PW. Effect of histamine H2-receptor antagonists on delayed hypersensitivity. Lancet 1: 624–626, 1978

    Article  PubMed  CAS  Google Scholar 

  • Bickel M, Herling AW, Schoelkens B, Scholtholt J. Chemical and biologic characteristics of roxatidine acetate. Scandinavian Journal of Gastroenterology 23 (Suppl. 146): 78–88, 1988

    Article  Google Scholar 

  • Billingham RE. Free skin grafting in mammals. In Billingham et al. (Eds) Transplantation of tissues and cells, pp. 1–26, The Wister Institute Press, Philadelphia, 1961

    Google Scholar 

  • Chu D, Wong WL, Mavligit GM. Abrogation of the local xenogeneic graft versus host reaction by preinjection of cimetidine to the immunosuppressed host rats: an experimental model for testing preclinical immunorestorative activity in vivo. Clinical Immunology and Immunopathology 45: 48–57, 1987

    Article  PubMed  CAS  Google Scholar 

  • Daniel WW. Biostatistics: a foundation for analysis in the health sciences, pp. 203–205, John Wiley & Sons Inc, New York, 1978

    Google Scholar 

  • Emeson EE, Weintraub FM, Likhite V. Effects of adrenalectomy and glucocorticosteroid therapy on bone marrow T-cells: effect on T-cell traffic and graft-versus-host (GVH) reactivity. Immunopharmacology 4: 311–321, 1982

    Article  PubMed  CAS  Google Scholar 

  • Gifford RRM, Tilberg AF. Histamine type-2 receptor antagonistimmune modulation II: cimetidine and ranitidine increase interleukin-2 production. Surgery 102: 242–247, 1987

    PubMed  CAS  Google Scholar 

  • Goldrosen MH, Gannon PJ, Lutz M, Holyoke ED. Isolation of human peripheral blood lymphocytes: modification of a double discontinuous density gradient of ficcol-hypaque. Journal of Immunological Methods 14: 15–17, 1977

    Article  PubMed  CAS  Google Scholar 

  • Jorizzo JL, Sams WM, Jegasothy BV, Olansky AJ. Cimetidine as an immuno-modulator: chronic mucocutaneous candidiasis as a model. Annals of Internal Medicine 92: 192–195, 1980

    PubMed  CAS  Google Scholar 

  • Khan MM, Melmon KL. Are autocoids more than theoretic modulators of immunity? Clinical Immunology Reviews 4: 1–30, 1985

    PubMed  CAS  Google Scholar 

  • Khan MM, Sansoni P, Engleman EG, Melmon KL. Pharmacologic effects of autocoids on subsets of T-cells. Journal of Clinical Investigation 75: 1578–1583, 1985

    Article  PubMed  CAS  Google Scholar 

  • Lampert IA, Janossy G, Suitters A, Bofill M, Palmer S, et al. Immunological analysis of the skin in graft versus host disease. Clinical and Experimental Immunology 50: 123–131, 1982

    PubMed  CAS  Google Scholar 

  • Lefford MJ. The measurement of tuberculin hypersensitivity in rats. International Archives of Allergy 47: 570–585, 1974

    Article  CAS  Google Scholar 

  • Mavligit GM, Calvo DB, Patt YZ, Hersh EM. Immune restoration and/or augmentation of local xenogeneic graft versus host reaction by cimetidine in vitro. Journal of Immunology 126: 2272–2274, 1981

    CAS  Google Scholar 

  • Mawhinney H, Killen M, Flemming WA, Roy AD. The hyperimmunoglobulin E syndrome: a neutrophil chemotactic defect reversible by histamine H2-receptor blockade? Clinical Immunology and Immunopathology 17: 483–491, 1980

    Article  PubMed  CAS  Google Scholar 

  • Rocklin RE. Modulation of cellular-immune responses in vivo and in vitro by histamine receptor-bearing lymphocytes. Journal of Clinical Investigation 57: 1051–1058, 1976

    Article  PubMed  CAS  Google Scholar 

  • Rocklin RE, Beer DJ. Histamine and immune modulation. Advances in Internal Medicine 28: 225–251, 1983

    PubMed  CAS  Google Scholar 

  • Rocklin RE, Habarek-Davidson A. Pharmacologic modulation in vitro of human histamine-induced suppressor cell activity. International Journal of Immunopharmacology 6: 179–186, 1984

    Article  PubMed  CAS  Google Scholar 

  • Sahasrabudhe DM, McCune CS, O’Donnell RW, Henshaw EC. Inhibition of suppressor T-lymphocytes (Ts) by cimetidine. Journal of Immunology 138: 2760–2763, 1987

    CAS  Google Scholar 

  • Schunack W. What are the differences between the H2-receptor antagonists. Alimentary Pharmacology and Therapeutics 1: 4935–5035, 1987

    Google Scholar 

  • Simon MR, Salberg DJ, Crane SA. In vivo cimetidine augmentation of phytohemagglutinin-induced human lymphocyte thymidine uptake. Transplantation 31: 400–403, 1981

    Article  PubMed  CAS  Google Scholar 

  • Snyman JR, Meyer EC, Schoeman HS. Cimetidine as modulator of the cell-mediated immune response in vivo using the tuberculin skin test as parameter. British Journal of Clinical Pharmacology 29: 257–260, 1990

    Article  PubMed  CAS  Google Scholar 

  • Streilein JW, Billingham RE. Cutaneous hypersensitivity reactions to cellular isoantigens in rats. Journal of Experimental Medicine 126: 445–473, 1967

    Article  Google Scholar 

  • Talpaz M, Medina JE, Patt YZ, Goepfert H, Guillamondegui OM, et al. The immune restorative effect of cimetidine administration in vivo on the local graft versus host reaction of cancer patients. Clinical Immunology and Immunopathology 24: 155–160, 1982

    Article  PubMed  CAS  Google Scholar 

  • Thompson RA, Kumararatne DS. Hyper-IgE syndrome and H2-receptor blockade. Lancet 2: 630, 1989

    Article  PubMed  CAS  Google Scholar 

  • Tonnesen H, Knigge U, Bulow S, Damm P, Fischerman K, et al. Effect of cimetidine on survival after gastric cancer. Lancet 2: 990–992, 1988

    Article  PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Pharmacology, University of Pretoria, P.O. Box 2034, Pretoria, 0001, South Africa

    J. R. Snyman & K. De Sommers

Authors
  1. J. R. Snyman
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. K. De Sommers
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Snyman, J.R., De Sommers, K. In Vivo Effect of Cimetidine and Roxatidine on the Allogeneic Graft-Versus-Host Reaction. Drug Invest. 3, 130–133 (1991). https://doi.org/10.1007/BF03259553

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF03259553

Keywords

Search

Navigation