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Adverse Effects of Two Long-Acting Depot Antipsychotic Drugs

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Summary

A comparison of the adverse effects of the depot preparations of flupenthixol decanoate (Depixol®) and fluphenazine decanoate (Modecate®) was conducted in 100 chronic schizophrenic patients attending the outpatient department at the Psychiatric Hospital, Bahrain.

Although akathisia, parkinsonism, weight gain and endocrine effects were seen in a large number of cases, there was no statistically significant difference in their incidence between the 2 groups. Furthermore, there was no difference in the efficacy of the 2 preparations studied.

We observed abnormal hair loss in 42 cases — 22 on Depixol® and 20 on Modecate®. This previously unreported side effect is probably due to these long-acting antipsychotic drugs.

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Authors and Affiliations

  1. Psychiatric Hospital, PO Box 26441, Bahrain

    Ahmed Shooka (Senior Registrar), M. K. Al Haddad & V. Mathur

  2. College of Medicine, Arabian Gulf University, Bahrain

    Ahmed Shooka (Senior Registrar), M. K. Al Haddad & V. Mathur

Authors
  1. Ahmed Shooka
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  2. M. K. Al Haddad
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  3. V. Mathur
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Shooka, A., Al Haddad, M.K. & Mathur, V. Adverse Effects of Two Long-Acting Depot Antipsychotic Drugs. Drug Invest. 6, 110–113 (1993). https://doi.org/10.1007/BF03258461

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