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Positron emission tomography with 4-[18F]fluoro-L-m-tyrosine in MPTP-induced hemiparkinsonian monkeys

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Abstract

PET imaging studies with 4-[18F]fluoro-L-m-tyrosine (FMT) in normal macaca monkeys showed selective accumulations of radioactivity in the striatum with time. In monkeys rendered hemiparkinsonian by intracarotid infusion of l-methyl-4-phenyl-l,2,3,6-tetrahydropyridine (MPTP), FMT uptake was eliminated in the lesioned striatum. FMT-PET studies were able to detect dopaminergic terminals in both normal and hemiparkinsonian monkeys, and clearly showed a reduction in aromatic L-amino acid decarboxylase (AAAD) activities in the MPTP-lesioned striatum. These results show that FMT is promising as a PET tracer for the evaluation of central dopaminergic systems in parkinsonism.

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Authors and Affiliations

  1. Department of Neurosurgery and Nuclear Medicine, Gunma University School of Medicine, Japan

    Nobuaki Hayase, Katsuyoshi Tomiyoshi, Kazushige Watanabe, Satoru Horikoshi, Takashi Shibasaki & Chihiro Ohye

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  1. Nobuaki Hayase
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  2. Katsuyoshi Tomiyoshi
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  3. Kazushige Watanabe
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  4. Satoru Horikoshi
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  5. Takashi Shibasaki
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  6. Chihiro Ohye
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Hayase, N., Tomiyoshi, K., Watanabe, K. et al. Positron emission tomography with 4-[18F]fluoro-L-m-tyrosine in MPTP-induced hemiparkinsonian monkeys. Ann Nucl Med 9, 119–123 (1995). https://doi.org/10.1007/BF03165037

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  • DOI: https://doi.org/10.1007/BF03165037

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