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Technetium-99m complex ofN-(2-pyridylmethyl)iminodiacetic acid as a new renal radiopharmaceutical

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Abstract

A tetradentate chelating agent constituting of an iminodiacetic acid group and a nitrogen atom of pyridine,N-(2-pyridylmethyl)iminodiacetic acid (PMIDA), was coordinated with99mTc and evaluated as a renal functional agent. The complex of PMIDA with99mTc was prepared by using a stannous chloride solution as a reducing agent. The chelating efficiency was analyzed by thin layer chromatography and electrophoresis. Chelation with99mTc resulted in a single radiochemical product. Biological studies were performed in mice and rats.99mTc-PMIDA was removed from the circulation solely by the kidneys. Clearance of99mTc-PMIDA from the blood and the kidneys was as rapid as that of99mTc-diethylenetriaminepentaacetic acid. The rate of blood clearance was unaffected by the administration of probenecid (a test for tubular secretion by the weak-acid mechanism), so that the glomerular filtration rate could be estimated by measuring its clearance from the blood. The results in animals with myohemoglobinuric acute renal failure suggested that99mTc-PMIDA might be a useful renal function radiopharmaceutical.

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Authors and Affiliations

  1. Faculty of Pharmaceutical Sciences, Fukuoka University, Nanakuma 8-19-1, Jonan-ku, 814-0180, Fukuoka, Japan

    Yoshiharu Karube, Koji Iwamoto & Jiro Takata

Authors
  1. Yoshiharu Karube
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  2. Koji Iwamoto
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  3. Jiro Takata
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Correspondence to Yoshiharu Karube.

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Karube, Y., Iwamoto, K. & Takata, J. Technetium-99m complex ofN-(2-pyridylmethyl)iminodiacetic acid as a new renal radiopharmaceutical. Ann Nucl Med 13, 127–132 (1999). https://doi.org/10.1007/BF03164890

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  • DOI: https://doi.org/10.1007/BF03164890

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