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Multiple endocrine neoplasia type 2 with malignant pheochromocytoma — Long term follow-up of a case by131I-meta-iodobenzylguanidine scintigraphy—

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Abstract

The case of a 33-year-old Japanese man, who has Multiple Endocrine Neoplasia Type 2 (MEN IIa) (Sipple’s syndrome) with malignant pheochromocytoma, is reported. He had survived for twelve years since the initial diagnosis of malignant pheochromocytoma. Within this period, he had undergone131I-meta-iodobenzylguanidine scintigraphy twice, in 1983 and 1990. This is the first case in Japan of a longterm surviving patient with malignant pheochromocytoma followed up by131I-MIBG scintigraphy. Although he had no exacerbation of clinical symptoms or urinary catecholamine levels, second scintigraphy clearly showed an increase in the tumor size, new metastasis of the malignant pheochromocytoma and exacerbation of the medullary thyroid carcinoma. Compared with any other roentgenological device and hormonal data,131I-MIBG scintigraphy was seen to be a good tool for evaluating the localization and the progression of tumors.131I-MIBG scintigraphy is a useful procedure not only for initial diagnosis but also for judging progression in a case of advanced malignant pheochromocytoma.

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Authors and Affiliations

  1. Department of Cell Physiology, Atomic Disease Institute, 7-1 Sakamoto-machi, Nagasaki-shi, 852, Nagasaki, Japan

    Hiroyuki Namba & Shunichi Yamashita

  2. The First Department of Internal Medicine, Nagasaki University School of Medicine, Japan

    Hideaki Kondo, Hironori Kimura, Naokata Yokoyama, Masako Tsuruta, Motomori Izumi & Shigenobu Nagataki

  3. Department of Radiology, Nagasaki University School of Medicine, Japan

    Hirofumi Kinoshita, Satomi Hakariya & Kuniaki Hayashi

  4. Ohita Prefecture Hospital, Japan

    Akira Sato

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  1. Hiroyuki Namba
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  2. Hideaki Kondo
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  3. Shunichi Yamashita
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  4. Hironori Kimura
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  5. Naokata Yokoyama
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  6. Masako Tsuruta
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  7. Akira Sato
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  8. Motomori Izumi
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  9. Hirofumi Kinoshita
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Namba, H., Kondo, H., Yamashita, S. et al. Multiple endocrine neoplasia type 2 with malignant pheochromocytoma — Long term follow-up of a case by131I-meta-iodobenzylguanidine scintigraphy—. Ann Nucl Med 6, 111–115 (1992). https://doi.org/10.1007/BF03164652

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  • DOI: https://doi.org/10.1007/BF03164652

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