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Talc inhalation is a life-threatening condition

  • Case Report
  • Published:
Pathology Oncology Research

Abstract

A case of rapidly progressive disease and pulmonary hypertension due to chronic cosmetic talc inhalation is presented. Although an uncommon cause of pulmonary hypertension, talc, especially through intravenous administration, should be included in the etiology of parenchymal pulmonary hypertension. In our case talc inhalation was inadvertent, causing fulminant disease leading to the patient’s death. To our knowledge, this is the first case of inadvertent talc inhalation causing death in adult patient.

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References

  1. Abraham JL, Brambilla C: Particle size for differentiation between inhalation and injection pulmonary talcosis. Environ Res 21: 94–96, 1980

    Article  PubMed  CAS  Google Scholar 

  2. Arnett EN, Battle WE, Russo JV, et al: Intravenous injection of talccontaining drugs intended for oral use. A cause of pulmonary granulomatosis and pulmonary hypertension. Am J Med 60: 711–718, 1976

    Article  PubMed  CAS  Google Scholar 

  3. Avolio G, Galietti F, Oliaro A, et al: Talcosis as an occupational disease. Case histories. Minerva Med 80: 269–273, 1989

    PubMed  CAS  Google Scholar 

  4. Bignon J, Brochard P: Pulmonary fibrosis and inorganic particles. Rev Fr Mal Respir 11: 371–382, 1983

    PubMed  CAS  Google Scholar 

  5. Canessa PA, Torraca A, Lavecchia MA, et al: Primary acute pulmonary cavitation in asymptomatic sarcoidosis. Sarcoidosis 6: 158–160, 1989

    PubMed  CAS  Google Scholar 

  6. Cotton WH, Davidson PJ: Aspiration of baby powder. N Engl J Med 313: 1662, 1985

    PubMed  CAS  Google Scholar 

  7. Crouch E, Churg A: Progressive massive fibrosis of the lung secondary to intravenous injection of talc. A pathologic and mineralogie analysis. Am J Clin Pathol 80: 520–526, 1983

    PubMed  CAS  Google Scholar 

  8. Egan AJ, Tazelaar HD, Myers JL, et al. Munchausen syndrome presenting as pulmonary talcosis. Arch Pathol Lab Med 123: 736–738, 1999

    PubMed  CAS  Google Scholar 

  9. Gibbs AE, Pooley FD, Griffiths DM, et al. Talc pneumoconiosis: a pathologic and mineralogic study. Hum Pathol 23:1344–1354, 1992

    Article  PubMed  CAS  Google Scholar 

  10. Gutermuth M, Schirg E, Steinbacher D, et al. Accidental aspiration of baby powder. Radiographic findings, preventive and therapeutic aspects. Intensivmed Prax 2: 83–92, 1980

    PubMed  Google Scholar 

  11. Hollinger MA: Pulmonary toxicity of inhaled and intravenous talc. Toxicol Lett 52: 121–127, 1990

    Article  PubMed  CAS  Google Scholar 

  12. Honda Y, Beau C, Delzell E, et al. Mortality among workers at a talc mining and milling facility. Ann Occup Hyg 46: 575–585, 2002

    Article  PubMed  CAS  Google Scholar 

  13. Hopkins GB: Pulmonary angiothrombotic granulomatosis in drag offenders. JAMA 221: 909–911, 1972

    Article  PubMed  CAS  Google Scholar 

  14. Lamb D, Roberts G: Starch and talc emboli in drag addicts’ lungs. J Clin Pathol 25: 876–881, 1972

    Article  PubMed  CAS  Google Scholar 

  15. Lundquest DE, Young WK, Edland JF: Maternal death associated with intravenous methylphenidate (Ritalin) and pentazocine (Talwin) abuse. J Forensic Sci 32: 798–801, 1987

    PubMed  CAS  Google Scholar 

  16. Magnan A, Ottomani A, Garbe L, et al. Respiratory failure in a HIV seropositive heroin addict female. Ann Fr Anesth Reanim 10: 74–76, 1991

    PubMed  CAS  Google Scholar 

  17. Motomatsu K, Adachi H, Uno T: Two infant deaths after inhaling baby powder. Chest 75: 448–450, 1979

    Article  PubMed  CAS  Google Scholar 

  18. Oubeid M, Bickel JT, Ingram EA, et al: Pulmonary talc granulomatosis in a cocaine sniffer. Chest 98: 237–239, 1990

    Article  PubMed  CAS  Google Scholar 

  19. Pairaudeau PW, Wilson RG, Hall MA, et al: Inhalation of baby powder: an unappreciated hazard. BMJ 302: 1200–1201, 1991

    Article  PubMed  CAS  Google Scholar 

  20. Pfenninger J, D’Apuzzo V: Powder aspiration in children. Report of two cases. Arch Dis Child 52: 157–159, 1977

    Article  PubMed  CAS  Google Scholar 

  21. Pickrell JA, Snipes MB, Benson JM, et al. Talc deposition and effects after 20 days of repeated inhalation exposure of rats and mice to talc. Environ Res 49: 233–245, 1989

    Article  PubMed  CAS  Google Scholar 

  22. Reyes de la Rocha S, Brown MA: Normal pulmonary function after baby powder inhalation causing adult respiratory distress syndrome. Pediatr Emerg Care 5: 43–48, 1989

    Article  PubMed  CAS  Google Scholar 

  23. Scancarello G, Romeo R, Sartorelli E: Respiratory disease as a result of talc inhalation. J Occup Environ Med 38: 610–614, 1996

    Article  PubMed  CAS  Google Scholar 

  24. Steele AA: Suicidal death by aspiration of talcum powder. Am J Forensic Med Pathol 11: 316–318, 1990

    Article  PubMed  CAS  Google Scholar 

  25. Wehner AP: Biological effects of cosmetic talc. Food Chem Toxicol 32: 1173–1184, 1994

    Article  PubMed  CAS  Google Scholar 

  26. Zazenski R, Ashton WH, Briggs D, et al: Talc: occurrence, characterization, and consumer applications. Regul Toxicol Pharmacol 21: 218–229, 1995

    Article  PubMed  CAS  Google Scholar 

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Authors and Affiliations

  1. Department of Pathology, Hasharon Hospital, Rabin Medical Center, Campus Golda, Petah Tikva

    Yoram Dekel, Lea Rath-Wolfson, Carlos Rudniki & Rumelia Koren

  2. Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel

    Yoram Dekel, Lea Rath-Wolfson, Carlos Rudniki & Rumelia Koren

Authors
  1. Yoram Dekel
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  2. Lea Rath-Wolfson
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  3. Carlos Rudniki
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  4. Rumelia Koren
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Correspondence to Rumelia Koren.

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Dekel, Y., Rath-Wolfson, L., Rudniki, C. et al. Talc inhalation is a life-threatening condition. Pathol. Oncol. Res. 10, 231–233 (2004). https://doi.org/10.1007/BF03033766

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  • DOI: https://doi.org/10.1007/BF03033766

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