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Retrospective evaluation of 5-fluorouracil-interferon-α treatment of advanced colorectal cancer patients

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Pathology & Oncology Research

Abstract

The authors describe the retrospective analysis of treatment by 5-fluorouracil and interferon-α of 34 patients with advanced colorectal cancer. An average of 4.6 treatment cycles (3–12) was applied. Complete remission was not observed; partial remission was observed in 8 patients; in 13 patients no change occurred and progression was detected in 14 cases. Remission rate was 22.8%, mean response time was 5.2 (3–12) months, mean progress-free survival 5.6 (0–22) months. Mean survival from the start of treatment was 11.9 (1–42) months and from the establishment of the diagnosis 26.1 (3–60) months. Severe life-threatening side-effects did not occur; other side-effects such as fever, nausea, diarrhea, leucopenia, and anemia responded to drugs. Treatment by 5-FU and interferon, in accordance with other authors’ findings, improved survival and well-being of patients but no breakthrough has been achieved.

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References

  1. Bleiberg H: Colorectal Cancer — Is there an alternative to 5FU? Eur J Cancer 33:536–541, 1997.

    Article  PubMed  CAS  Google Scholar 

  2. Burke D, Allan-Mersh TG. Colorectal liver metastases. Postgrad Med J 72:464–469, 1996.

    Article  PubMed  CAS  Google Scholar 

  3. Gamelin EC, Danquechin-Dorval EM, et al: Relationship between 5FU dose intensity and therapeutic response in patients with advanced colorectal cancer receiving infusional therapy containing 5FU. Cancer 77:441–451, 1996.

    Article  PubMed  CAS  Google Scholar 

  4. Dufour P andHusseini F. 5-fluorouracil plus alpha interferon as treatment of metastatic colorectal carcinoma. Ann Oncol 7:575–579, 1996.

    PubMed  CAS  Google Scholar 

  5. Ferguson JE, Hulse P, Lorigan P, et al: Coninuous infusion of 5 fluorouracil with alpha 2b interferon for advanced colorectal carcinoma. Brit J Cancer 72:193–197, 1995.

    PubMed  CAS  Google Scholar 

  6. Jaeck D, Bachellier P, Guiguet M, et al: Long-term survival following resection of coloretal hepatic metastases. British J Surg 84:977–980, 1997.

    Article  CAS  Google Scholar 

  7. Kemeny N, Jounes A, Seiter K, et al: Interferon alpha 2a and 5 fluorouracil for advanced colorectal carcinoma. Assesment of activity and toxicity. Cancer 66:2470–2475, 1990.

    Article  PubMed  CAS  Google Scholar 

  8. Meadows ML, Linley C: Biochemical and pharmacolgic modulation of fluorouracil by alpha interferon. Advanced colorectal cancer: The role of alpha interferons. Schering Plough International 18:10–14, 1992.

    Google Scholar 

  9. Niederle N, Kreuser ED, Meadows LM, et al: Advanced colorectal cancer. The role of alpha interferons. Schering Plough International 18:14–18, 1992.

    Google Scholar 

  10. Pazdur R, Ajani JA, Patt YZ: Phase II study of fluorouracil and recombinant interferon alpha 2a in previously untreated advanced colorectal carcinoma. J Clin Oncol 8:2027–2031, 1990.

    PubMed  CAS  Google Scholar 

  11. Piga A, Cascinu S, Latini L, et al: A phase II randomised trial of 5-fluorouracil with or without intferon alpha-2a in advanced colorectal cancer. British J Cancer 74:971–974, 1996.

    CAS  Google Scholar 

  12. Raderer M, Scheithauer W: Treatment of advanced colorectal cancer with 5-fluorouracil and interferin alpha: an overview of clinical trials. Eur J Cancer 31:1002–1008, 1995.

    Article  Google Scholar 

  13. Ragnhammar P, Blomgren H, Edler D, et al: Different dose regimens of 5-fluorouracil and interferon alpha in patients with metastatic colorectal carcinoma. Eur J Cancer 31:310–320, 1995.

    Article  Google Scholar 

  14. Schmoll HJ: Development of treatment of advanced colorectal cancer: 5-FU infusional and the role of new agents. Eur J Cancer 32:18–22, 1996.

    Article  Google Scholar 

  15. Schuller J, Czejka M: Influence of interferon 2b on pharmacocintics of 5-Fluorouracil. Advanced colorectal cancer. The role of alpha interferons. Schering Plough International 18:6–10, 1993.

    Google Scholar 

  16. Stadler W, Coffier B, Pazdur R: Therapeutic advantages in oncology. ASCO Congress Report Series 1997; 2–9, 1997.

    Google Scholar 

  17. van Triest B, van Groeningen CJ, Pinedo HM: Current chemoterapeutic possibilities in the treatment of colorectal cancer. Eur J Cancer 31:1193–1197, 1995.

    Article  Google Scholar 

  18. Wadler S, Wiernik PM: Clinical update on the role of fluorouracil and recurrent interferon alpha 2a in the treatment of colorectal cancer. Semin Oncol 8:2027–2031, 1990.

    Google Scholar 

  19. Woll PJ, Pettengell R: Interferons in oncology. J Clin Oncol 15:1432–1438, 1997.

    Google Scholar 

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Authors and Affiliations

  1. 2nd Department of Surgery, Medical Faculty, University of Debrecen, Hungary

    István Takács

  2. 3rd Department of Internal Medicine, Medical Faculty, University of Debrecen, Hungary

    Csilla András, Zoltán Csiki, István Gál, Lajos Antal & Gyula Szegedi

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  1. Csilla András
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  2. Zoltán Csiki
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  3. István Gál
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  4. István Takács
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  5. Lajos Antal
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  6. Gyula Szegedi
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András, C., Csiki, Z., Gál, I. et al. Retrospective evaluation of 5-fluorouracil-interferon-α treatment of advanced colorectal cancer patients. Pathol. Oncol. Res. 6, 175–178 (2000). https://doi.org/10.1007/BF03032369

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  • DOI: https://doi.org/10.1007/BF03032369

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