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Disseminated metastatic disease of osteosarcoma of the femur in the abdomen: Unusual metastatic pattern on Tc-99m MDP bone scan

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Abstract

A 25-year-old patient with osteosarcoma of the right distal femur underwent a bone scintigraphy with Tc-99m methylene diphosphonate (MDP). Whole-body bone scan revealed extensive metastatic disease in the abdominal region. Abdominal computerized tomography confirmed the presence of ascites and calcified masses on the greater omentum and peritoneal surfaces. Here we describe a case of unusual metastatic pattern of an osteosarcoma showing extensive intraabdominal metastases without prominent lung involvement after intensive chemotherapy.

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References

  1. Vander Griend RA. Osteosarcoma and its variants.Orthop Clin North Am 1996; 27: 575–581.

    Google Scholar 

  2. Weis LD. Common malignant bone tumors: osteosarcoma. In:Surgery for Bone and Soft-Tissue Tumors. Simon MA, Springfield D (eds), Philadelphia; Lippincott-Raven, 1998: 265–274.

    Google Scholar 

  3. Brown ML. Bone scintigraphy in benign and malignant tumors.Radiol Clin North Am 1993; 31: 731–738.

    PubMed  CAS  Google Scholar 

  4. Wang K, Allen L, Fung E, Chan CC, Chan JC, Griffith JF. Bone scintigraphy in common tumors with osteolytic components.Clin Nucl Med 2005; 30: 655–671.

    Article  PubMed  CAS  Google Scholar 

  5. Marina N, Prat C, Rao B. Improved prognosis of children with osteosarcoma metastatic to the lung(s) at the time of diagnosis.Cancer 1992; 70: 2722–2727.

    Article  PubMed  CAS  Google Scholar 

  6. Jeffree GM, Price HG, Sisson HA. The metastatic patterns of osteosarcoma.Br J Cancer 1975; 32: 87–107.

    PubMed  CAS  Google Scholar 

  7. Tabone MD, Kalifa C, Rodary C. Osteosarcoma recurrences in pediatric patients previously treated with intensive chemotherapy.J Clin Oncol 1994; 2: 2614–2620.

    Google Scholar 

  8. Jaffe N, Smith E, Abelson HT, Frei E 3rd. Osteogenic sarcoma: alterations in the pattern of pulmonary metastases with adjuvant chemotherapy.J Clin Oncol 1983; 1:252–254.

    Google Scholar 

  9. Pratt C, Shanks E, Hustu O, Rivera G, Smith J, Kumar AP. Adjuvant multiple drug chemotherapy for osteosarcoma of the extremity.Cancer 1977; 39: 51–57.

    Article  PubMed  CAS  Google Scholar 

  10. Bacci G, Avella M, Picci P. Metastatic patterns in osteosarcoma.Tumori 1988; 74: 421–427.

    PubMed  CAS  Google Scholar 

  11. Danzinger J, Wallace S, Handel SF, deSantos LA. Metastatic osteogenic sarcoma to the brain.Cancer 1979; 43: 707–710.

    Article  Google Scholar 

  12. Nouyrigat P, Berdah J, Roullet B, Olivier J. Osteosarcoma with calcified regional lymph nodes.Pediatr Radiol 1993; 23: 74–75.

    Article  PubMed  CAS  Google Scholar 

  13. Daw NC, Kaste SC, Hill DA, Kun LE, Pratt CB. Metastatic osteosarcoma to the liver after treatment for synovial sarcoma: a case report.Pediatr Hematol Oncol 2001; 18: 123–128.

    Article  PubMed  CAS  Google Scholar 

  14. Lockhart SK, Coan JD, Jaffe N, Eftekhari F, David C, Shirkhoda A. Osteosarcoma metastatic to the kidney.Clin Imaging 1989; 13: 154–156.

    Article  PubMed  CAS  Google Scholar 

  15. Takaue Y, Slopis JM, Anzai T, Robertson R, Jaffe N. Successful treatment of pulmonary and abdominal metastatic osteosarcoma.Med Pediatr Oncol 1985; 13: 126–128.

    Article  PubMed  CAS  Google Scholar 

  16. Panizo-Santos A, Sola I, Lozano M, de Alava E, Pardo J. Metastatic osteosarcoma presenting as a small-bowel polyp. A case report and review of the literature.Arch Pathol Lab Med 2000; 124: 1682–1684.

    PubMed  CAS  Google Scholar 

  17. Eltabbakh GH, Belinson JL, Biscotti CV. Osteosarcoma metastatic to the ovary: a case report and review of the literature.Int J Gynecol Pathol 1997; 6: 76–78.

    Article  Google Scholar 

  18. Uribe-butero G, Russell W, Sutow W. Primary osteosarcoma of bone: a clinicopathological investigation of 243 cases, with necropsy studies in 54.Am J Clin Pathol 1977; 67: 427–435.

    Google Scholar 

  19. Lin JT, Yen CC, Wang WS, Chiou TJ, Liu JH, Wu HT, et al. Case report: Unusual peritoneal spreading by metastatic osteosarcoma of the tibia.Br J Radiol 2003; 76: 337–338.

    Article  PubMed  Google Scholar 

  20. Costa CM, de Camargo B, Bagietto R, Alcantra PS, Chojniak R, Sredni ST. Abdominal recurrence of osteogenic sarcoma: a case report.J Pediatr Hematol Oncol 1998; 20: 271–273.

    Article  PubMed  CAS  Google Scholar 

  21. Teates C, Brower A, Williamson B. Osteosarcoma extraosseous metastases demonstrated on bone scan and radiographs.Clin Nucl Med 1977; 2: 298–302.

    Article  Google Scholar 

  22. Hough D. Multifocal osteosarcoma with extensive pleural metastatic disease.Austral Radiol 1992; 36: 147–149.

    Article  CAS  Google Scholar 

  23. Westra A, Schrijvers D, Somville J, Van Schil P, Hubens G, Van Oosterom A. Late peritoneal metastasis in a patient with osteosarcoma.Ann Oncol 1998; 9: 907–911.

    Article  PubMed  CAS  Google Scholar 

  24. Spieth ME, Ansari AN, Forrester DM, Kimura RL, Assassa GS, Siegel ME. Osteosarcoma presenting as intestinal obstruction.J Nucl Med 1993; 34: 1990–1991.

    PubMed  CAS  Google Scholar 

  25. Maredia R, Ward DL, Moreno AJ, Carpenter AL. Extensive extraskeletal osteosarcoma in the liver and abdomen as demonstrated by bone scintigraphy.Clin Nucl Med 1997; 22:717–718.

    Article  PubMed  CAS  Google Scholar 

  26. Giuliano AE, Feig S, Eilber FR. Changing metastatic pattern of osteosarcoma.Cancer 1984; 54: 2160–2164.

    Article  PubMed  CAS  Google Scholar 

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Authors and Affiliations

  1. Departments of Nuclear Medicine, Gulhane Military Medical Academy and School of Medicine, 06018, Etlik, Ankara, Turkey

    Ozgur Karacalioglu, Seyfettin Ilgan, Ozdes Emer & Mehmet Ozguven

  2. Departments of Medical Oncology, Gulhane Military Medical Academy and School of Medicine, 06018, Etlik, Ankara, Turkey

    Okan Kuzhan

Authors
  1. Ozgur Karacalioglu
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  2. Seyfettin Ilgan
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  3. Okan Kuzhan
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  4. Ozdes Emer
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  5. Mehmet Ozguven
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Correspondence to Ozgur Karacalioglu.

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Karacalioglu, O., Ilgan, S., Kuzhan, O. et al. Disseminated metastatic disease of osteosarcoma of the femur in the abdomen: Unusual metastatic pattern on Tc-99m MDP bone scan. Ann Nucl Med 20, 437–440 (2006). https://doi.org/10.1007/BF03027380

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  • DOI: https://doi.org/10.1007/BF03027380

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