Abstract
The immunosuppressive effects on cell-mediated immunity of alfathesin, when used as the sole agent for short-term anaesthesia, were investigated in ten women undergoingpregnancy termination. Cell-mediated immunity was evaluated by E rosette formation in peripheral blood (reflecting the percentage of T lymphocytes) and by proliferalive responses to the mitogens concanavalin A and phyto-haemagglulinin in various concentrations. Measurements were made before alfathesin was administered, and again after 60 minutes, two days and seven days. Significant reductions in the percentage of E rosettes in peripheral blood and in mitogenic responses to concanavalin A were observed 60 minutes after administration of alfathesin. A model is proposed in which alfathesin binds to lymphocytic membrane receptors, thus affecting in vitrocell-mediated immune reactions.
Résumé
L’effet immunosupressif de l’alfathesin, sur l’immunité par médiation céllulaire, quand celui-ci est employé comme agent unique de l’anesthésie de courte durrée, fait l’objet de cet étude. L’immunités par mediation cellulaire a été évaluée par la formation de rosettes E dans le sang périferique (ce qui reflète le pourcentage de lymphocytes T) et par la réponse proliférative aux mitogenes concanavaline A et phyto-aglutininne dans des concentralions variables. Les mesurements ont été fait avant l’administration de l’alfathesin, et puis après 60 minutes, deux et, réspectivement sept jours. Des réductions significatifes dans le pourcentage des rosettes E dans le sang périferique et dans la réponse mitogéne a la concanavaline A ont été observées 60 minutes après l’administration de l’alfathesin. Un modèle est proposé dans lequel l’alfathesin se lie aux récepteurs lymphocitaires de la membrane, et, de cette manière affecte les réactions immunitaires par mediation céllulaire in-vitro.
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Rosenfeld, A., Handzel, Z.T., Konichezky, S. et al. Cell-mediated immune suppression due to alfathesin in short-term anaesthesia. Can Anaesth Soc J 30, 522–525 (1983). https://doi.org/10.1007/BF03007088
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DOI: https://doi.org/10.1007/BF03007088