Summary
Cross-over experiments performed in dogs showed that Doxapram hydrochloride in a single-dose injection was as effective asd- amphetamine in shortening the recovery time from a standardized dose of thiopental anaesthesia and was more effective than methylphemdate in the dosages that were compared No untoward effects were observed in any of these experiments
When Doxapram hydrochloride was used m an intravenous infusion method for 50 healthy female patients following an elective dilatation and curettage of the uterus, the drug was effective for stimulating respirations (both tidal volume and respiration rate) without producing any appreciable circulatory changes In four instances, there were signs of central nervous system irritation which subsided promptly upon discontinuation of the Doxapram infusion
An appreciable difference in the lime for full recovery to occur was found between patients receiving the analeptic and others who did not Direct clinical observation leaves no doubt that an arousal effect is produced which persists along with the augmented breathing response However, an accelerated recovery from thiopental anaesthesia is not a prominent effect with respect to the expected recovery time because it did not appreciably reduce the total “sleeping time” following a double “sleep dose” of thiopental in humans
Résumé
A la suite d’expériences croisées chez des chiens, nous avons constaté que le chlorhydrate de doxapram, administré en une seule dose, était aussi efficace que l’amphétamine pour accélérer le réveil à la suite d’une anesthésie produite par une dose standard de thiopental et était plus efficace que le phénidate de méthyl à des doses comparables Au cours de ces expériences, nous n’avons pas observé d’effets secondaires
Chez 50 malades en bonne santé, opérées pour dilatation et curetage, nous avons employé le chlorhydrate de doxaprajm en perfusion endoveineuse, nous avons observé une stimulation de la respiration (l’air courant et le rythme) sans changement circulatoire important Chez quatre malades, des signes d’irritation du système nerveux central sont apparus, mais, en arrêtant la perfusion, ils sont disparus rapidement
Nous avons observé une différence appréciable dans le délai du réveil complet chez les malades qui avaient reçu l’analeptique et chez ceux qui ne l’avaient pas reçu L’observation clinique directe nous permet d’affirmer qu’il se produit un réveil qui persiste et ainsi qu’une augmentation des échanges respiratoires Toutefois, un réveil précoce d’une anesthésie au thiopenfal ne constitue pas un factetur important si i’on considère le délai normal prévu pour le réveil, le médicament n’a pas diminué, de façon appréciable, la durée du sommel chez l’humain, à la suite d’une double dose de thiopental
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Evers, W., Malik, K. & Dobkin, A.B. Influence of doxapram hydrochloride on recovery from Thiopental anaesthesia. Can Anaes Soc J 12, 281–287 (1965). https://doi.org/10.1007/BF03004143
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DOI: https://doi.org/10.1007/BF03004143