Skip to main content
SpringerLink
Log in

Oncogens in ENT and head and neck — a review

  • Guest editorial
  • Published:
Indian Journal of Otolaryngology and Head & Neck Surgery Aims and scope Submit manuscript

Abstract

With the exploration of new horizons in the frontiers of genetic linkage with head and neck cancer by advanced molecular biological technique it may be possible to know the various steps involved in the cancer development and new prognostic markers for not only predicting prognosis but also progression and predisposition including routine diagnostic tests for mutantgenes for a better diagnosis and treatment of squamous cell cancers of head and neck. Various oncogens and their products so far identified are ras, myc, c-erb, Bl, PRAD-.l, int-2, hst-1 and p 53 etc with lirikage to head and neck malignancy. The HLA gene association is the most convincing evidence for the role of genetics in the aetiology of nasopharyngeal cancer. EGFR looks to be a promising prognostic indicator as its interaction with the polypeptide epidermal growth factor stimulates proliferation of target cells.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

References

  1. Rose E.A. (1991): Application of the polymerase chain reaction to genome analysis. Fuseb. J., 5, 46–54.

    CAS  Google Scholar 

  2. Southern E.M. (1975): Detection of specific sequences among DNA fragments separated by gel electrophoresis. J. Mol. Biol., 98, 503–517.

    Article  PubMed  CAS  Google Scholar 

  3. Kumar R. & Dunn L.L. (1989): Designed diagnostic restriction fragment length polymorphism for the detection of point mutations in ras oncogens. Oncogen Res., 4, 235–241.

    CAS  Google Scholar 

  4. Saranath D., Panchal R. G., Nair R., Mehta A. R., Sanghavi V. & Deo, M. G. (1990): Restriction fragment length polymorphism of the L-myce gene in oral cancer patients. Br. J. Cancer, 61 530–533.

    PubMed  CAS  Google Scholar 

  5. Zur Hausen H. (1991): Viruses in human cancers. Science, 254, 1167–1173.

    Article  PubMed  CAS  Google Scholar 

  6. GAaffey M.J. & Weiss L.M. (1990): Viral oncogenesis : Epsetin-Barr virus. Am. J. Otolarygol, 11, 375–381.

    Article  Google Scholar 

  7. Kashima H.K., Kutcher M., Kesiss T., Levin L. S., De Vivviers E.M. & Shah K. (1990): Human papilloma virus in squamous cell carcinoma, leukoplakia, lichen planus and clinically normal epithelium of the oral cavity. Ann. Otol. Rhinol. Laryngol, 99, 55–61.

    PubMed  CAS  Google Scholar 

  8. Batsakis J.G., Raymon A. K. & Rice D.H. (1983): The pathology of head and neck tumours : paillomas of the upper urodigestive tract. Head and Neck Surgery, 5, 332 : 9 344.

    Article  PubMed  CAS  Google Scholar 

  9. Rous P. (1991): A sarcoma of the fowl transmissible by an agent separable from the tumour cells. J. Exp. Med., 13, 397–411.

    Article  Google Scholar 

  10. Weinberg R.A. (1989): Oncogens, antioncogens and the molecular causes of multistep carcinogenesis. Cancer Res. 49, 3713–3721.

    PubMed  CAS  Google Scholar 

  11. Rothman K.G. & Kellar A. Z (1987): The effect of joint exposure to alcohol and tobacco on the risk of cancer of the mouth and paharynx. J. Chronic Diseases, 25, 711–716.

    Article  Google Scholar 

  12. Hill C., Benhamout E. & Doyon F. (1991): Trends in cancer mortality in France : 1950-1985. Br. J. Cancer, 63, 587–590.

    PubMed  CAS  Google Scholar 

  13. Boss J.L. (1989): ras oncogens in hitman cancer-a review. Cancer Res., 49, 4682–4689.

    Google Scholar 

  14. Kristen w. h. & Mayer L.A. (1967): Morphologic response to a a murine erythroblastosis virus. J. Nat. Cancer Inst., 39, 311–335.

    Google Scholar 

  15. Harvey J.J. (1964)): An unidentified virus which causes the rapid production of tumour in mice. Nature, 204, 1104–1105

    Article  PubMed  CAS  Google Scholar 

  16. jussawalla D. J. & Deshapande D.S. (1971): Evaluation of the cancer risk in tobacco chewers and smokers-an epidemiologic assessment. Cancer, 28, 244–252.

    Article  PubMed  CAS  Google Scholar 

  17. Petro R., Lopez A.D., Boreham J., Thun M. & Heath C. Jr (1992): Mortality from tobacco in developed countries : Indirect estimation from national vital statistics. Lancet, 339, 1268–1278.

    Article  Google Scholar 

  18. Field J. K., Spandidos D.A. & Lamothe A. (1986): Clinical relevance of oncogen expression in head and neck tumours. Anti-Cancer Res., 6, 595–600.

    CAS  Google Scholar 

  19. Cole, M.D. (1986): The myc oncogen : its role in transformation and differentiation. Ann. Rev. Genet., 20, 361–384.

    Article  PubMed  CAS  Google Scholar 

  20. Carpenter G. & Chohen S. (1979): Epidermal growth factor, Annu. Rev. Biochem., 48, 193–216.

    Article  PubMed  CAS  Google Scholar 

  21. Cohen S. (1962): Isolation of a mouse submaxillary gland protein accelerating incisor eruption and eyelid opening in the newborn animal. J. Biol. Chem., 237, 1555–1562.

    PubMed  CAS  Google Scholar 

  22. Rheinwald J. G. & Green H. (1977): Epidermal growth factor and the multiplication of cultured human epidermal kerationcytes. Nature 265, 421–424.

    Article  PubMed  CAS  Google Scholar 

  23. Limas C. (1991): Relationship of EGFR detectability with the A,B, 1+ blood group antigen. Am. J. Path. 139, 131–137.

    PubMed  CAS  Google Scholar 

  24. Partridge M., Gullick W.J., Langdon J.D., & Sherriff M. (1984): Expression of EGFR on oral squamous cell carcinoma. Br. J. Oral Maxillofac. Surg., 26, 381–389.

    Article  Google Scholar 

  25. Cowley G., Smith J.A., Gusterson B., Hendler F. & Ozannne B. (1988): The amount of EGFR is elevated on squamous cell carcinoma. Cancer Cells, 1, 5–10.

    Google Scholar 

  26. Santini J., Formento J.L., Francoval M., Milano G., Schneider M., Dassonville O. & Demarda F. (1991): Characterization, quantification and potential clinical use of EGFR in head and neck SCCs. Head Neck, 13, 132–139.

    Article  PubMed  CAS  Google Scholar 

  27. Karawamoto T., Takahasi K., Nishi M., Kimura T., Matsumara T. & Taniguchi S. (1991): Quantitative assay of EGFR in human SCCs of the oral regions by an avianbiotin method, J.J. Cancer Res., 82, 403–410.

    Google Scholar 

  28. Okano M., Theli G.M., Davis J.R., Grierson H. L. & Purtilo D.G. (1988) : EBV and human disease : recent advances on diagnosis. Clin. Microbiol Reviews, 300–312.

  29. Ulman E.V. (1923): On the aetiology of laryngeal paillomata. Acta Octolaryngol, 6, 317–325.

    Google Scholar 

  30. Lack E.E., Jenson A.B., Smith H.G., Healy G.B., Pass F & Vawter G.F. (1980): The Immunoperoxidase localization of human papilloma virus in laryngeal papilloma. Intervirology, 14, 148–154.

    Article  PubMed  CAS  Google Scholar 

  31. Scheffner M., Werness B.A., Humbregtse J.M., Levine A.J. & Howley P.M. (1990): The E6 oncoprotein encoded by human papillomaviral types, 16 & 18 promotes the degradation of p53, cell 63. 1129–1136.

    Article  PubMed  CAS  Google Scholar 

  32. Werness B.A., Levine A.J. & Howley P.M. (1990): Association of human papilloma virus types 16 & 18E6 proteins with p53. Science, 248, 76–79.

    Article  PubMed  CAS  Google Scholar 

  33. Oren M., Maltman W. & Levine A.J. (1981): The p53 tumour suppressor gene. Mol. Cell Biol., 8, 530–531.

    Google Scholar 

  34. Lane O.P. & Crawford L.V. (1979): T antigen is bound to a host protein in SV 40 transformed cells. Nature 178, 261–263.

    Article  Google Scholar 

  35. Weichselbaum R.R., Dunphy E.J., Beckett M.A., Tybor A.G., Moran W.J., Goldman M.E., Vokes E.E. & Panjeow R. (1989): EGFR gene amplification and expression in head and neck cancer cell lines. Head and Neck Surg, 11, 427–432.

    Google Scholar 

  36. Ishitoya J., Toriyama K., Oguchi N., Kitamura K., Oshmiha M., Asano K. & Yamamotto T. (1991): Gene amplification and overexpression of EGFR in SCCs of head and neck. Br. J. cancer, 59, 559–562.

    Google Scholar 

  37. Miyaguchi M., Olofsson J. & Hellqist H.B. (1990): Expression of EGFR in laryngeal dysplasia and carcinoma. Acta Otolaryngol., 110, 309–313.

    Article  PubMed  CAS  Google Scholar 

  38. Yamada, K., Iwai K., Okad Y. & Mori M. (1989): Immunohistochemical expression of EGFR in salivary gland tumours. Virchovts Arch. (A), 415, 523–531.

    Article  CAS  Google Scholar 

  39. Syrjanen K.J. (1987): Review human papilloma virus infections and their association with squamous cell neoplasia. Arch., 57, 417–444.

    CAS  Google Scholar 

  40. Lindberg H., Fey S.J., Ottosen, P.D. & Mose Larsen P. (1988): HPV and carcinoma of head and neck, Clin. Otolaryngol, 13, 447–454.

    Article  Google Scholar 

  41. Howley P.M. (1991): Role of HPVin human cancer. Cancer Res. Suppl., 51, 5019–5022.

    Google Scholar 

  42. Park N.H., Min B.M., Li S.L., Huang M.Z., Cherick H.M. & Doniger J. (1991): Immortalization of normal human oral keratinocytes with type 16 HPV. Carcinogenesis, 12, 1631–1727.

    Article  Google Scholar 

  43. Munger K., Philips W.C. Bubb V., Howley P.M. & Schlegel R. (1989): The E6 and E7 genes of the HPV type 16 together are necessary and sufficient for transformation of primary human keratinocytes. J. Virol, 63, 4417–4421.

    PubMed  CAS  Google Scholar 

  44. Hollstein M.C., Metacalf R.A., Welsh J.A., Montesan O.R. & Harris C.C. (1990): Frequent mutation of the p53 gene in human esophageal cancer. Pro. Natl. Acad. Sci., USA, 87 9958–9961.

    Article  CAS  Google Scholar 

  45. Field J.K., Spandidos D.A., Malliri A., Gonsney J.R., Yiagnisis M., & Steli P.M. (1991): Elevated p53 expression correlates with a history of heavy smoking in squamous cell carcinomas of head and neck. Br. J. Cancer, 64, 573–577.

    PubMed  CAS  Google Scholar 

  46. Gusterson B.A., Anbazhagan R., Warren W., Midgely C., Lane D.P., O’ Hare M., Stamps A., Carter R., & Jayatilakae H. (1991): Expression of p53 in premalignant and malignant squamous epithelium. Oncogen, 6, 1785–1789.

    CAS  Google Scholar 

  47. SakAi E. & Tsuchinda N. (1992): Most human squamous cell carcinomas in the oral cavity contain muted p53 tumour suppressor genes. Oncogen, 7, 927–933.

    CAS  Google Scholar 

  48. Masiero R., dolcetti R., gasparotto D., doglioni c, pellucchi s., barzan l., grandi e. & boiochi m. (1992): High frequencey of p53 gene alteration associated with protein overexpression in hnuman SCCs of larynx. Oncogen, 7, 1159–1166.

    Google Scholar 

  49. L.J. Clark (1993): Oncogens and ENT : a review of the molecular biological advances in SCCs of head and neck. Clin. Otolaryngol., 18, 4–13.

    Article  PubMed  CAS  Google Scholar 

  50. Chan S.H. & Simons J.J. (1977): Immunogenetics of nasopharyngeal carcinoma. Annals of Academy of Medicine, Singapore, 6, 342–346.

    Google Scholar 

  51. Payne R., Radvany R., & Grumet C (1975): A new second loins HLA -A antigen in linkage disequilibrium with HLA-A2 in Cantonese Clenese. Tissae Antigen, 5, 69–71.

    Article  CAS  Google Scholar 

  52. Zeng Y., Zhang E.G., wu Y.C., Huang Y.S., Huang N. Q., LI J. Y. et al (1985): Prospective studies on NPC in EBV lga/VCA antibody-positive persons in Wuzhou city, China. International Journal of Cancer, 36, 545–547.

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Rajah Muthiah, Medicai College & Hospital, Annamalai University, 608 002, Chidambaram, Tamilnadu

    G. C. Sahoo

Authors
  1. G. C. Sahoo
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Sahoo, G.C. Oncogens in ENT and head and neck — a review. IJO & HNS 50, 320–325 (1998). https://doi.org/10.1007/BF03000681

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF03000681

Key Words

Search

Navigation