Abstract
The influence of immobilization stress on the lipid composition of alveolar surfactant and lungs in rats immobilized for 12 and 24 hours, the effects of phospholipase A2, and lipid transfer activity in alveolar surfactant were investigated. The results indicate that alveolar surfactant phospholipids underwent more significant alterations compared to lung phospholipids. Furthermore, phospholipase A2 and lipid transfer activity were reduced in alveolar surfactant of immobilized rats. The reported data suggest that the lower lipid transfer activity might be responsible for the reduced phospholipids in the surfactant system.
Similar content being viewed by others
References
Ackerman S. J. and Shindledecker, B. D. (1987) Chronociologic factors in experimental stress ulcer.Chronobiology International, 4, 3–10.
Amir, Sh., Amit, Z., and Brom, Z. W. (1981) Stress. Endorphines and Psychosis. Mod. Probl. Pharmacopsychiatry,17, 192–210.
Baevski, R. M., Kirilov, O. I., and Kleckin, S. Z. (1984) Mathematical analysis of the changes of heart rhythm during stress. Moscow: “Kauka.“
Birkun, A. A., Nesterov, E. N., and Kobozev, G. V. (1981) Lung surfactant. Zdorovja, Kiev.
Boyadjieva, N. and Ovtcharov, R. (1987) Effect of some benzodiazepines on the secretion of thyrotropic hormone and prolactin under conditions of experimental stress.Acta Physiologica Pharmacologica Bulgaria, 13, 18–21.
Caddell, J. L., Blanchette-Mackie, E. J., Snowden, K. I., and Jackson, N. N. (1987) Pulmonary lesion induced by stress in magnesium-deficient rats: A light- and electron-microscopic study.American Journal of Pathology, 127, 430–440.
Echternkamp, S. E. (1984) Relationship between luteinizing hormone and cortisone in acutely stressed beef cows.Theriogenologie, 22, 305–312.
Etoh, T., Kahishita, E., and Nagi, K. (1984) Role of alveolar macrophage plasmalogen activator in the acute pulmonary responses to endotoxin lung.162, 49–58.
Grosse, A., Bianchi, J. M., Diaz Puerta de Grosse, C. S., Iglesia, G. E., and Coviello, A. (1987) Vascular reactivity of hypertensive patients treated with thiazides, beta blockers, and clinidine during psychological experimental stress situation. Seventh Scientific Meeting of the Inter-American Society of Hypertension, Burnos Aires, May 10 to 13, 1987.Hypertension, 9, 526.
Hass, M. A., and Massard, D. (1988) Regulation of the synthesis of superoxide dismutases in rat lungs during oxidant and hyperthermic stress.Journal of Biological Chemistry, 236, 776–781.
Kohovkova, J., and Odavic, R. (1969) A simple method for analysis of phospholipids separated by thin-layer chromatography.Journal of Chromatography, 40, 90–95.
Koumanov, K., Boyanov, A., Neicheva, T., Markovska, T., and Momchilova, A. (1983) Maternal diabetes mellitus and changes in neonatal rat lung and alveolar surfactant phospholipids.Bulletin European de Physiopathologie Respiratoire, 19, 447–451.
Kudriashov, J. A. (1987) Capacity function of venous vessels of the skeletal musculature in experimental venous insufficiency and immobilization stress.Patologicheska Fiziologia, 4, 27–30.
Lowry, O. H., Rosenbrough, N. J., Farr, A. L., and Rendal, R. J. (1951) Protein measurement with the folin reagent.Journal of Biological Chemistry, 15, 61–65.
Nicolov, N., and Sudakov, K. (1985) Emotional stress. “Medizina i fizkultura,“ Sofia.
Nicolov, N., and Deleva, J. (1986) Neuromodulators, arterial hypertension, and emotional stress.Neuroscience, 12, 1–25.
O’Bovle, C. A., Harris, D., Barry, H., and Gullen, J. J. (1986) Differential effect of benzodiazepine sedation in high- and low-anxious patients in a real-life stress setting.Psychopharmacology, 88, 226–229.
Schroter, R. C., Robertshaw, D., Baker, M. A., Shoemaker, V. H., Holmes, R., and Schmidt-Nielsen, K. (1987) Respiration in heat-stressed camels.Respiration Physiology, 70, 97–112.
Sudakov, K. B. (1981) System mechanisms of emotional stress. Moscow: Medizina.
Vagin, J. E., Coplik, E. V., and Vediaev, D. F. (1984) Study of the rhythm of breathing in rats under acute emotional stress.Experimental Biology, 97, 524–525.
Vagin, J. E. (1987) Informational value of frequency and irregularity of respiratory rhythm at physical and emotional stress in man.J. Vish. Nerv. Deiatel. 37, 975–978.
Yamamoto, H. (1987) An influence of catecholaminergic nervous activation on the mucosal blood flow of gastric body in the experimental stress ulcer model.Tokyo Jikeikai Med. J., 102, 779–794.
Yanev, E., Momchilova, A., Koumanov, K., Novelli, G., and Nicolov, N. (1980) N-t-Butyl-Phenilnitrone antioxidant effect on the alterations in phospholipid composition of alveolar surfactant and lungs in endotoxin shock rats. Novelli and Ursini (Eds.),Oxygen Free Radicals in Shock. International Workshop, Florence, 1985. Basel: Karger, 193–196.
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Yanev, E., Momchilova-Pankova, A., Markovska, T. et al. Influence of immobilization stress on the phospholipid composition of alveolar surfactant and lungs in rats. Pav. J. Biol. Sci. 25, 25–28 (1990). https://doi.org/10.1007/BF02999813
Issue Date:
DOI: https://doi.org/10.1007/BF02999813