Abstract
Isocitrate lyase (ICL) is envisaged as an attractive drug target for the development of antimicrobial agents. We have prepared a series of hydroquinone derivatives on the basis of the structure of halisulfates, a naturally occurring inhibitor of ICL. The obtained derivatives were evaluated against ICL ofC. albicans. The preliminary structure-activity relationships and the minimal structural requirements for potency were established through structural modifications.
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Yang, HC., Yu, J., Oh, KB. et al. Synthesis and evaluation of hydroquinone derivatives as inhibitors of Isocitrate Lyase. Arch Pharm Res 30, 955–961 (2007). https://doi.org/10.1007/BF02993963
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DOI: https://doi.org/10.1007/BF02993963