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Monoclonal antibodies in the management of carcinoma patients

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Abstract

The use of monoclonal antibodies (MAbs) in the clinical management of carcinoma patients is reported in the present review. Among the various MAbs generated, MAb B72.3 (LTIB, National Cancer Institute, U.S.A.) has been extensively used in clinical trials either for antigen identification (TAG-72) in sera, or for tumor localization in carcinoma patients. Serum assay results, in colorectal cancer patients, showed the usefulness of the MAb B72.3 in monitoring the clinical course of the malignant disease. Its specific tumor localization (70% of the biopsy specimens) and the immunoscintigraphy studies, afterin vivo administration, have also been discussed. The positive results obtained, markedly contributed in the development of a new intraoperative methodology termed “radioimmunoguided surgery”.

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Authors and Affiliations

  1. Department of Surgery, II University of Rome, School of Medicine, c/o S. Eugenio Hospital, P.le DeirUmanesimo 10, 00144, Rome, Italy

    Mario Roselli, Carlo U. Casciani, Oreste Buonomo, Beniamino Iorio, Alessandra Diodati & Vincenzo Vittorini

  2. Regina Elena Cancer Institute, Rome, Italy

    Fiorella Guadagni & David Colcher

  3. Laboratory of Tumor Immunology and Biology, National Cancer Institute, NIH, 20892, Bethesda, MD, USA

    John W. Greiner, David Colcher & Jeffrey Schlom

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  1. Mario Roselli
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  2. Carlo U. Casciani
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Roselli, M., Casciani, C.U., Guadagni, F. et al. Monoclonal antibodies in the management of carcinoma patients. Med. Oncol. & Tumor Pharmacother. 8, 223–228 (1991). https://doi.org/10.1007/BF02987190

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  • DOI: https://doi.org/10.1007/BF02987190

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