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Synthesis andin vitro cytotoxicity of 2-alkylaminosubstituted quinoline derivatives

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  • Medicinal Chemistry & Natural Products
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Abstract

Eight 2-alkylaminosubstituted 5,8-dimethoxy-4-methylquinolines and nine 2-alkylaminosub-stituted or 2,6-disubstituted 4-methylquinoline-5,8-diones were synthesized and evaluatedin vitro cytotoxicity against four human cancer cell lines (HOP62, SK-OV-3, HCT15 and SF295).

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Authors and Affiliations

  1. College of Pharmacy, Chungbuk National University, 361-763, Cheongju, Korea

    Heesoon Lee, Jeeman Lee & Seoung -Soo Hong

  2. College of Medicine, Kunkuk University, 380-701, Chungju, Korea

    Sung -Il Yang

  3. College of Pharmacy, Chungnam National University, 305-764, Taejon, Korea

    Sang -Hun Jung

  4. College of Pharmacy, Yeoungnam University, 712-749, Gyongsan, Korea

    Yurngdong Jahng

  5. College of Medicine, Dongguk University, 780-714, Gyongju, Korea

    Jungsook Cho

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  1. Heesoon Lee
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  2. Jeeman Lee
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  3. Seoung -Soo Hong
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  4. Sung -Il Yang
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  5. Sang -Hun Jung
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  6. Yurngdong Jahng
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  7. Jungsook Cho
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Correspondence to Heesoon Lee.

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Lee, H., Lee, J., Hong, S.S. et al. Synthesis andin vitro cytotoxicity of 2-alkylaminosubstituted quinoline derivatives. Arch Pharm Res 23, 450–454 (2000). https://doi.org/10.1007/BF02976570

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  • DOI: https://doi.org/10.1007/BF02976570

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