Abstract
2-(Allylthio)pyrazine derivatives were designed as a novel cancer chemopreventive agent that functions through selective inhibtion of cytochrome P-450 and induction of phase II enzymes involved in the detoxification of carcinogens. A practical preparation method of 2-(allylthio) pyrazine derivatives was established by the reaction of 2-mercaptopyrazine and allylbromides in the presence of a catalytic antioxidant, DABCO (1,4-diazabicyclo[2,2,2] octane), in dimethyl-formamide at below 50°C.
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Lee, J.W., Lee, B. & Kim, N.D. Synthesis of 2-(allylthio)pyrazines as a novel cancer chemopreventive agent. Arch Pharm Res 24, 16–20 (2001). https://doi.org/10.1007/BF02976487
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DOI: https://doi.org/10.1007/BF02976487