Skip to main content
SpringerLink
Log in

Gm typing of irish coeliac patients and controls does not help locate the “second” coeliac gene

  • Published:
Irish Journal of Medical Science Aims and scope Submit manuscript

Abstract

A two gene model has been proposed to explain the inheritance of coeliac disease (CD). One gene is on chromosome 6 in the MHC complex (HLA associated). It has been suggested the second gene is located on chromosome 14, in or near the region encoding for immunoglobulin heavy chain allotypes (Gm types). In a study of 102 unrelated Irish coeliacs and a group of ethnic controls, we have failed to show an association of CD with any particular Gm type or types. There is no evidence to confirm that a gene on chromosome 14 is implicated in the inheritance of CD.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Greenberg, D. A. & Lange, K. L. A maximum likelihood test of the two-locus model of coeliac disease. Am. J. Med. Genet 1982: 12, 75–82.

    Article  PubMed  CAS  Google Scholar 

  2. Kagnoff, M. F., Weiss, J. Brown, R. J., Lee, T., Schanfield, M. S. Immunoglobulin allotype markers in gluten sensitive enteropathy. Lancet 1983: i, 952–953.

    Article  Google Scholar 

  3. Weiss, J. Austin, R. K., Schanfield, M. S., Kagnoff, M. F. Gluten sensitive enteropathy: IgG heavy chain (Gm) allotypes and the immune response to wheat gliadin. J. din, Invest. 1983: 72, 96–101.

    CAS  Google Scholar 

  4. Fedrick, J. A., Pandey, J. P., Verkasalo, M., Teppo, A. M., Fudenberg, H. H. Immunoglobulin allotypes and the Immune response to wheat gliadin in a Finnish population with coeliac disease. Expl. Clin. Immunogenet. 1985: 2, 185–190.

    CAS  Google Scholar 

  5. Schanfield, M. S. Genetics markers of human immunoglobulins. In Fundenberg, H. H. Stites, D. P., Caldwell, J. L & Wells, J. V., eds. Basic and Clinical Immunology, 2nd ed. Lange Medical: Los Altos, 1978: 59–65.

    Google Scholar 

  6. Pandey, J. P., Shannon, T., Arala-Chaves, M. P., ba]Fudenberg, H. H. Gm and Km frequencies in a Portugese population. Human Genet. 1982; 61, 154–156.

    Article  CAS  Google Scholar 

  7. Carbonara, A. O., ba]De Marchi, M. van Loghem, E., Ansaldi, N. Gm markers in coeliac disease. Hum. Immunol, 1983: 6, 91–95.

    Article  PubMed  CAS  Google Scholar 

  8. Hetzel, P. A. S., Bennett, G. D., Sheldon, A. Propert, D. N., Brown, R., Hay, J. A., Gabb, B., Davidson, G. P., Schanfield, M. S., LaBrooy, J. T., Shearman, D. J. Genetic markers in Australian Caucasian subjects with coeliac disease. Tissue Antigens 1987: 30, 18–22.

    Article  PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. University Department of Medicine, University College Hospital, Galway, Ireland

    M. Hannigan, M. Bourke, F. M. Stevens & C. F. McCarthy

Authors
  1. M. Hannigan
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. M. Bourke
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. F. M. Stevens
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. C. F. McCarthy
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Hannigan, M., Bourke, M., Stevens, F.M. et al. Gm typing of irish coeliac patients and controls does not help locate the “second” coeliac gene. I.J.M.S. 160, 57–58 (1991). https://doi.org/10.1007/BF02947649

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF02947649

Keywords

Search

Navigation