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Clinical use of fibronectin

Potential applications

  • Published:
Ricerca in clinica e in laboratorio

Summary

There is considerable experimental evidence that the RES is an important host defense system in critical illness. The role of fibronectin in the control of RES phagocytic function and the potential for fibronetin therapy to ameliorate or reverse multisystem organ failure in critically ill patients are less well documented. This documentation may be difficult to accrue in the clinical setting because of the multifactorial problems of individual critically ill patients and the heterogeneity of underlying diseases in such patients. More work needs to be done in animal models in which these variables can be controlled. Large scale production of pasteurized biologically active fibronection should be possible32 if the cryoprecipitate studies prove the clinical utility of fibronectin concentrates. Fibronectin will certainly not be a panacea for critically ill patients, but the addition of any useful substance to the now meager armamentarium would be most welcome.

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  1. Department of Medicine, University of Wisconsin, 1300 University Avenue, 53706, Madison, Wis., USA

    Deane F. Mosher & Jeffrey E. Grossman

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  1. Deane F. Mosher
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Mosher, D.F., Grossman, J.E. Clinical use of fibronectin. La Ricerca Clin. Lab. 13, 43–54 (1983). https://doi.org/10.1007/BF02904744

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