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Behavior of new type of rock wool (HT wool) in lungs after exposure by nasal inhalation in rats

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Environmental Health and Preventive Medicine Aims and scope

Abstract

Objectives

Previous types of rock wool has been recently replaced with high-temperature wool (HT wool). HT wool is characterized by a chemical composition with a higher concentration of Al2O3 and a lower concentration of SiO2, lower biopersistence, and a higher melting point than previous types of rock wool. To evaluate the safety of HT wool, an asbestos substitute, we examined the biopersistence of HT wool in the lungs, based on changes in fiber count according to the length and fiber size (length and width), by performing a nose-only inhalation exposure study in rats.

Methods

Male Fischer 344 rats were exposed to fibers at the target exposure concentration of 30 mg/m3 continuously for 3 hours daily for 5 consecutive days. Rats were sacrificed shortly after exposure, and 1, 2, and 4 weeks after exposure, and their lung tissues were incinerated at a low temperature. Then, fiber counts and sizes in the lungs were analyzed using a phase contrast microscope.

Results

The fiber count in the lungs 4 weeks after exposure significantly decreased from the baseline value (shortly after exposure). The half-life of fibers calculated from the approximation curve was 34 days for all fibers and 11 days for fibers longer than 20 μm.

Conclusions

Both the length and width significantly decreased 4 weeks after exposure, probably because fibers were ingested by alveolar macrophages, discharged to outside of the body by mucociliary movement, or lysed by body fluid. In future studies, it is necessary to examine the long-term persistence of fibers in the lungs.

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References

  1. Doll R. Mortality from lung cancer in asbestos workers. Br J Ind Med. 1993;50:485–490.

    PubMed  CAS  Google Scholar 

  2. Planning Division, Air Quality Bureau, Ministry of the Environment (ed). All about Asbestos and Zeolite. Kawasaki: Japan Environmental Sanitation Center; 1987. p. 1–476.

    Google Scholar 

  3. Morinaga K, Kohvama N. Healtheare for Workers Handling Asbestos. Tokyo: The Occupational Health Promotion Foundation; 1993. p. 141–166.

    Google Scholar 

  4. Berry G. Mortality of workers certified by pneumoconiosis medial panels as having asbestosis. Br J Ind Med. 1981;38: 130–137.

    PubMed  CAS  Google Scholar 

  5. Gormley IP, Bolton RE, Brown GM, Davis JM, Wright A. Some observations on the in vitro cytotoxicity of chrysotile prepared by the wet dispersion process. Environ Health Perspect. 1983;51:35–39.

    Article  PubMed  CAS  Google Scholar 

  6. Koshi K, Sakabe H. Effect of asbestos dusts on the cultured macrophages. Ind Health. 1972;10:16–23.

    Google Scholar 

  7. Planning Division, Air Quality Bureau, Ministry of the Environment (ed). All about Asbestos Substitutes. Kawasaki: Japan Environmental Sanitation Center; 1989. p. 106–109.

    Google Scholar 

  8. Man-made Vitrous Fibers. IARC Monographs on the Evaluation of Carcinogenic Risks to Humans. Vol. 81. Lyon: IARC; 2002.

    Google Scholar 

  9. Hesterberg TW, Hart GA. Synthetic vitreous fibers: a review of toxicology research and its impact on hazard classification. Crit Rev Toxicol. 2001;31:1–53.

    Article  PubMed  CAS  Google Scholar 

  10. Kamstrup O, Ellehauge A, Chevalier J, Davis JM, McConnell EE, Thevenaz P. Chronic inhalation studies of two types of stone wool fivers in rats. Inhal Toxicol. 2001;13:603–621.

    PubMed  CAS  Google Scholar 

  11. Kamstrup O, Ellehauge A, Bellmann B, Chevalier J, Davis JM. Subchronic inhalation study of stone wool fibers in rats. Ann Occup Hyg. 2004;48:91–104.

    Article  PubMed  CAS  Google Scholar 

  12. Knudsen T, Guldberg M, Christensen VR, Jensen SL. New type of stonewool (HT fibers) with a high dissolution rate at pH=4.5. Glastech Ber Glass Sci Technol. 1996;69:331–337.

    CAS  Google Scholar 

  13. Kohyama N, Tanaka I, Tomita M, Kudo M, Shinohara Y. Preparation and characteristics of standard references samples of fibrous minerals for biological experiments. Ind Health. 1997;35:415–432.

    Article  PubMed  CAS  Google Scholar 

  14. Kudo Y, Kohyama N, Sakamoto Y, Nakajima Y, Shibata K, Miki T, et al. Behavior of rock wool in lungs after exposure by nasal inhalation in rats. J Occup Health. (in press)

  15. The Environmental Improvement Office, Industrial Safety and Health Department, Ministry of Labor (ed). Mineral Dusts. Guidebook for Working Environment Measurement I, Tokyo: Japan Association for Working Environment Measurement; 2000. p. 167–180.

    Google Scholar 

  16. Homma K. Experimental study for preparing metal fumes. Ind Health. 1966;4:129–137.

    Article  CAS  Google Scholar 

  17. Kamstrup O, Davis JM, Ellehauge A, Guldberg M. The biopersistence and pathogenicity of man-made viterous fibers after short- and long-term inhalation. Ann Occup Hyg. 1998; 42:191–199.

    PubMed  CAS  Google Scholar 

  18. McConnell EE, Kamstrup O, Musselman R, Hesterberg TW, Chevalier J, Miiller WC, et al. Chronic inhalation study of size-separated rock and slag wool insulation fibers in Fishcher 344/N rats. Inhal Toxicol. 1994;6:571–614.

    Article  CAS  Google Scholar 

  19. Hesterberg TW, Miiller WC, Musselman RP, Kamstrup O, Hamilton RD, Thevenaz P. Biopersistence of man-made vitreous fibers and crocidolite asbestos in the rat lung following inhalation. Fundam Appl Toxicol. 1996;29:267–279.

    Article  PubMed  CAS  Google Scholar 

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Authors and Affiliations

  1. Department of Preventive Medicine and Public Health, Kitasato University School of Medicine, 1-15-1, Kitasato, 228-8555, Sagamihara, Kanagawa, Japan

    Yuichiro Kudo, Kaori Shibata, Takeo Miki, Mio Ishibashi, Kaori Hosoi, Toshihiko Sato & Yoshiharu Aizawa

  2. Faculty of Economy, Toyo University, Tokyo, Japan

    Norihiko Kohyama

Authors
  1. Yuichiro Kudo
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  2. Kaori Shibata
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  3. Takeo Miki
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  4. Mio Ishibashi
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  5. Kaori Hosoi
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  6. Toshihiko Sato
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  7. Norihiko Kohyama
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  8. Yoshiharu Aizawa
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Correspondence to Yuichiro Kudo.

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Kudo, Y., Shibata, K., Miki, T. et al. Behavior of new type of rock wool (HT wool) in lungs after exposure by nasal inhalation in rats. Environ Health Prev Med 10, 239–248 (2005). https://doi.org/10.1007/BF02897697

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  • DOI: https://doi.org/10.1007/BF02897697

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