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Phase I toxicity and pharmacology study of trimethylcolchicinic acid in patients with advanced malignancies

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Summary

A phase I study of trimethylcolchicinic acid (TMCA) given orally once daily for 5 days every 3rd week was performed in 19 patients with advanced malignancies. Myelosuppression and mucositis were the major toxicities observed. Serum TMCA levels were monitored and appear to be useful in predicting toxicities. A partial response was seen in one lymphoma patient and stabilization of disease was noted in one patient each with prostatic and ovarian cancer.

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Authors and Affiliations

  1. Departments of Hematology/Oncology, School of Medicine, University of Southern California, 90 057, Los Angeles, California, USA

    Eddie Hu, Peter Rosen, Susan Jeffers, Mark Scholtz & Franco Muggia

  2. Departments of Hematology/Oncology, School of Pharmacy, University of Southern California, 90 057, Los Angeles, California, USA

    Richard Ko & Robert Koda

Authors
  1. Eddie Hu
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  2. Richard Ko
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  3. Robert Koda
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  4. Peter Rosen
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  5. Susan Jeffers
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  6. Mark Scholtz
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  7. Franco Muggia
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Additional information

Supported in part by NIH DRR GCRC grant MOI RR-43

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Hu, E., Ko, R., Koda, R. et al. Phase I toxicity and pharmacology study of trimethylcolchicinic acid in patients with advanced malignancies. Cancer Chemother Pharmacol 26, 359–364 (1990). https://doi.org/10.1007/BF02897294

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  • DOI: https://doi.org/10.1007/BF02897294

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