Summary
In order to investigate the regulating role of Astragapolysaccharide (APS) in the mice model of asthmatic airway inflammation, the airway eosinophil number, spleen T lymphocyte proliferation, level of IL-2 production and their relationships were studied in sensitized mice and sensitized mice treated with different concentrations of APS. The results showed that the number of eosinophils as well as lymphocytes in the airway of the sensitized animals were significantly increased, and a marked positive correlation between the inflammation cells and spleen T lymphocyte proliferation was found. Moreover, there was a positive correlation between inflammation cells and the level of IL-2 production. The APS of given dosage could significantly reduce the number of eosinophils in the airway of the sensitized animals. At the same time the level of IL-2 secreted by spleen T lymphocytes stimulated with ConA was also significantly decreased and there was a marked positive correlation between them. Our results suggested that APS of given dosage could prevent antigen-induced the number of eosinophils infiltrating into the airway of sensitized mice and inhibit the proliferation and activation of lymphocyte and IL- 2 production. Through its immuno-regulating effect, APS can be helpful in the treatment of asthma.
Similar content being viewed by others
References
Zuany-Amorim C, Haile’s Leduc D. Interleukin-10 inhibits antigen-induced cell recruitment into the airways of sensitized mice. J Clin Invest, 1995, 95:2644
Ohsawa F, Widmer H, Knusel Bet al. Response of embryonic rat hippocampal neurons in culture neurotropain 3, brain-derived neurotrophic factor and basic fibroblast growth factor. Neuroscience, 1993, 57:67
Virchow J C, Walker C, Hafner Det al. T cells and cytokines in bronchoalveolarvage fluid after segmental allergen provocation atopic asthma. Am J Respir Crit Care Med, 1995, 151:960
Street N E, Schumacher J Het al. Helerogeneity of mouse helper T cells. Evidenle from bulk cultures and Uniting ditution cloning for preursors of Th1 and limiting Th2 dilution cells. J Immunol, 1990, 144:1629
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Jianmin, X., Yongjian, X., Zhenxiang, Z. et al. The effect of Astragapolysaccharide on the lymphocyte proliferation and airway inflammation in sensitized mice. Journal of Tongji Medical University 19, 20–22 (1999). https://doi.org/10.1007/BF02895587
Received:
Issue Date:
DOI: https://doi.org/10.1007/BF02895587