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The influence of bursectomy and thymectomy on the primary antibody formation to various antigens

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Abstract

Neonatal bursectomy and irradiation led to a negative antibody response to bovine serum albumin andSalmonella paratyphi A. In the case of immunization with ΦX 174 phage and sheep erythrocytes a substantial depression of antibody formation was recorded. In addition, neonatal thymectomy and irradiation partially depressed the antibody response to BSA,Salmonella paratyphi A and ΦX 174 phage, on immunization with sheep erythrocytes the ability to form antibodies was almost uninfluenced

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References

  • Benedict, A. A., Brown, R. J., Hersh, R.:The temporal synthesis and some chromatographic and ultracentrifugal characteristics of chicken antibodies. J. Immunol. 90: 399, 1963a.

    PubMed  CAS  Google Scholar 

  • Benedict, A. A., Brown, R. J., Hersh, R.:Inactivation of high and low molecular weight chicken antibodies by mercaptoethanol. Proc. Soc. exptl. Biol. Med. 113: 136, 1963b.

    CAS  Google Scholar 

  • Claflin, A. J., Smithies, O., Meyer, R. K.:Antibody responses in bursa-deficient chickens. J. Immunol. 97: 693, 1966.

    PubMed  CAS  Google Scholar 

  • Cooper, M. D., Peterson, R. D. A., Good, R. A.:Delineation of the thymic and bursal lymphoid system in the chicken. Nature 205: 143, 1965.

    Article  PubMed  CAS  Google Scholar 

  • Cooper, M. D., Peterson, R. D. A., South, M. A., Good, R. A.:The function of the thymus system and the bursa system in the chickens. J. exptl. Med. 123: 75, 1966.

    Article  CAS  Google Scholar 

  • Crumpton, M. J., Davies, D. A. L., Hutchison, A. M.:The serological specifities of Pasteurella pseudotuberculosis somatic antigens. J. gen. Microbiol. 18: 129, 1958.

    PubMed  CAS  Google Scholar 

  • Davies, D. M. L., Crumpton, M. J.:The adsorption of bacterial polysaccharides by erythrocytes. Immunology 1: 157, 1958.

    PubMed  CAS  Google Scholar 

  • Eyckmans, L., Schonne, E., Eyssen, H.:Antibody production in bursectomized chickens after injection of bacteriophage ΦX 174. Life Sciences 7: 161, 1968.

    Article  CAS  Google Scholar 

  • Glick, B., Chang, T. S., Jaap, R. G.:The bursa of Fabricius and antibody production. Poultry Sci. 35: 224, 1956.

    Google Scholar 

  • Graetzer, M. A., Wolfe, H. R., Aspinall, R. L., Meyer, R. K.:Effect of thymectomy and bursectomy on precipitin and natural hemagglutinin production in the chicken. J. Immunol. 90: 878, 1963.

    PubMed  CAS  Google Scholar 

  • Hájek, P.:Properties fo the neutralizing factors against T2 and ΦX 174 phages present in normal sera. Fol. microbiol. 11: 290, 1966.

    Article  Google Scholar 

  • Hall, C. E., Maclean, E. C., Tessman, I.:Structure and dimension of bacteriophage ΦX 174 from electron microscopy. J. mol. Biol. 1: 192, 1959.

    Article  Google Scholar 

  • Isaković, K., Janković, B. D., Popesković, L., Milošević, D.:Effect of neonatal thymectomy, bursectomy and thymo-bursectomy on hemagglutinin production in chickens. Nature 200: 273, 1963.

    Article  PubMed  Google Scholar 

  • Isaković, K., Janković, B. D.:Role of the thymus and the bursa Fabricius in immune reactions in chickens. II. Cellular changes in lymphoid tissues of thymectomized, bursectomized and normal chickens in the course of first antibody responses. Int. Arch. Allergy & appl. Immunol. 24: 296, 1964.

    Google Scholar 

  • Janković, B. D., Isaković, K.:Role of the thymus and the bursa of Fabricius in immune reactions in chickens. I. Changes in lymphoid tissues of chickens surgically thymectomized at hatching. Int. Arch. Allergy & appl. Immunol. 44: 278, 1964.

    Google Scholar 

  • Janković, B. D., Isaković, K.:Antibody production in bursectomized chickens given repeated injections of antigen. Nature 211: 202, 1966.

    Article  PubMed  Google Scholar 

  • Janković, B. D., Isaković, K.:Natural haemagglutining in surgically bursectomized and thymectomized chickens. Fol. microbiol. 13: 401, 1967.

    Google Scholar 

  • Marvanová, H., Hájek, P.:The effect of bursa Fabricii and thymus on the development of immunological reaction. Wissenschaftliche Zeitschrift der Friedrich-Schiller-Universität Jena, Mathematisch-Naturwissenschaftliche Reihe, 17: 167, 1968.

    Google Scholar 

  • Metcalf, D.:Long term effect of whole-body irradiation on lymphocyte homeostasis in the mouse. Radiation Res. 10: 313, 1959.

    Article  PubMed  CAS  Google Scholar 

  • Ortega, L. G., Der, B. K.:Studies of a gammaglobulinemia induced by ablation of the bursa of Fabricius. Fed. Proc. 23: 546, 1964.

    Google Scholar 

  • Papermaster, B. W., Friedman, D. I., Good, R. A.:Relationship of the bursa of Fabricius to immunologic responsiveness and homograft immunity in the chickens. Proc. Soc. exptl. Biol. Med. 110: 62, 1962.

    CAS  Google Scholar 

  • Peterson, R. D., Burmester, B. R., Frederickson, T. N., Purchose, H. G., Good, R. A.:Effect of bursectomy and thymectomy on the development of visceral lymphomatosis in the chicken. J. Nat. Canc. Inst. 32: 1343, 1964.

    CAS  Google Scholar 

  • Rose, M. E., Orlans, E.:Normal immune responses of bursaless chickens to a secondary antigenic stimulus. Nature 217: 1, 1968.

    Article  Google Scholar 

  • Stavisky, A. B.:Micromethods for the study of proteins and antibodies. I. Procedure and general applications of hemagglutination and hemagglutination-inhibition reactions with tannic acid and protein-treated red blood cells. J. Immunol. 72: 360, 1954.

    Google Scholar 

  • St. Pierre, R., Ackerman, G. A.:Influence of bursa implantation upon lymphocytic nodules and plasma cells in spleens of bursectomized chickens. Proc. Soc. exptl. Biol. Med. 122: 1280, 1966.

    CAS  Google Scholar 

  • Szenberg, A., Warner, N. L.:Dissociation of immunological responsiveness in fowls with a hormonally arrested development of lymphoid tissues. Nature 194: 146, 1962.

    Article  Google Scholar 

  • Springer, G. F., Horton, R. E., Forbes, M.:Origin of antihuman blood group B agglutinin in “germ-free” chickens. Ann. N. Y. Acad. Sci. 78: 272, 1959.

    Article  PubMed  CAS  Google Scholar 

  • Šidák, Z., Vondráček, J.:A simple nonparametric test of the difference of location, of two populations. Aplikace matematiky (Prague), 2: 215, 1957.

    Google Scholar 

  • Tromans, W. J., Horne, R. W.:Structure of bacteriophage ΦX 174. Virology 15: 1, 1961.

    Article  PubMed  CAS  Google Scholar 

  • Van Alten, P. J., Cain, W. A., Good, R. A., Cooper, M. D.: “Gamma globulin production and antiboyd synthesis in chickens bursectomized as embryos.” Nature 217: 358, 1968.

    Article  PubMed  Google Scholar 

  • Warner, N. L., Szenberg, A., Burnet, F. M.:The immunological role of different lymphoid organs in chicken. I. Dissociation of immunological responsiveness. Austr. J. exptl. Biol. Med. Sci. 40: 373, 1962.

    Article  CAS  Google Scholar 

  • Warner, N. L., Szenberg, A.:Effect of neonatal thymectomy on the immune response in the chicken. Nature 196: 784, 1962.

    Article  PubMed  CAS  Google Scholar 

  • Warner, N. L.:The immunological role of the avian thymus and bursa of Fabricius. Fol. Biol. (Praha) 13: 1, 1967.

    CAS  Google Scholar 

  • Westphal, O., Lüderitz, O., Bister, F.:Über die Extraktion von Bakterien mit Phenol/Wasser. Z. Naturforsch. 7b: 148, 1952.

    CAS  Google Scholar 

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Marvanová, H., Hájek, P. The influence of bursectomy and thymectomy on the primary antibody formation to various antigens. Folia Microbiol 14, 171–178 (1969). https://doi.org/10.1007/BF02892887

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