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An experimental comparative study on the characteristics of ventricular fibrillation during cardiac arrest and methoxamine administration

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Summary

The effect of a pure α-adrenergic agent, methoxamine on ventricular fibrillation (VF) amplitude and the relation between hemodynamic parameters and survival in a rodent cardiopulmonary resuscitation (CPR) model were studied. Our results suggested that: 1) VF amplitude decreased during untreated VF, but it increased during pericardial chest compression; 2) methoxamine significantly increased the mean aortic pressure (MAP) and coronary perfusion pressure (CPP) but not VF amplitude, and the survival also increased due to elevation of CPP; and 3) all surviving animals with successful defibrillation had a higher VF amplitude.

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Authors and Affiliations

  1. Department of Thoracic and Cardiac Surgery, Tongji Hospital, Tongji Medical University, 430030, Wuhan

    Pan Tiecheng

  2. Department of Rehabilitation, Xiehe Hospital, Tongji Medical University, 430022, Wuhan

    Zhou Shuhua

  3. University Hospital of Basel, Switzerland

    Martin von Planta, Wolfang Studer & Daniel Scheidgger

Authors
  1. Pan Tiecheng
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  2. Zhou Shuhua
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  3. Martin von Planta
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  4. Wolfang Studer
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  5. Daniel Scheidgger
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Additional information

This project was supported by grants from the Swiss National Research foundation (No. 32-32359. 91).

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Tiecheng, P., Shuhua, Z., von Planta, M. et al. An experimental comparative study on the characteristics of ventricular fibrillation during cardiac arrest and methoxamine administration. Current Medical Science 17, 94–97 (1997). https://doi.org/10.1007/BF02888243

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  • DOI: https://doi.org/10.1007/BF02888243

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