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Effects of Isophenphos-I on the respiratory function of rat liver mitochondria

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Summary

The effects of insecticide Isophenphos-I on respiration of rat liver mitochondria were studied. It was found that Isophenphos-I inhibited the respiration of mitochondria both in vivo and in vitro, and reduced the activities of glutamate dehydrogenase, succinate dehydrogenase, succinatecytochrome C reductase and Mg++-ATPase in vitro. The effects of the insecticide on the permeability and lipid peroxidation of the mitochondrial membrane were also investigated in vitro in order to explore the possible mechanism of the respiratory inhibition of mitochondria by the insecticide.

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Rei-ming, L., Yu-gu, L. Effects of Isophenphos-I on the respiratory function of rat liver mitochondria. Journal of Tongji Medical University 8, 18–23 (1988). https://doi.org/10.1007/BF02887772

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