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The study of inhibition of DNA synthesis by hydroxyurea(s)

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Abstract

A novel method for the study of inhibition of DNA synthesis by hydroxyurea(s) using topological indices and frontier molecular orbital energies:E homo,E lumo andE total is described. The data suggest that the inhibitory activities of urea(s) can be successfully modelled by these molecular descriptors. Excellent results are obtained in multivariate systems as well as upon introducing a dummy parameter.

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Authors and Affiliations

  1. Department of Chemistry, APS University, 486 003, Rewa, India

    Vijay K Agrawal, Shahnaz Bano & Keshav C Mathur

  2. Research Division, Laxmi Pest & Fumigation Pvt. Ltd., 3 Khatipura, 452 007, Indore, India

    Padmakar V Khadikar & Sneha Karmarkar

  3. Department of Chemistry, Holkar Model and Autonomous College, 452 001, Indore, India

    Manorama Mandloi

  4. Institute of Chemical Sciences, DAVV, 452 001, Indore, India

    Nitin S Sapre

Authors
  1. Vijay K Agrawal
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  2. Shahnaz Bano
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  3. Keshav C Mathur
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  4. Padmakar V Khadikar
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  5. Sneha Karmarkar
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  6. Manorama Mandloi
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  7. Nitin S Sapre
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Correspondence to Padmakar V Khadikar.

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Agrawal, V.K., Bano, S., Mathur, K.C. et al. The study of inhibition of DNA synthesis by hydroxyurea(s). Proc. Indian Acad. Sci. (Chem. Sci.) 111, 697–708 (1999). https://doi.org/10.1007/BF02871284

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  • DOI: https://doi.org/10.1007/BF02871284

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