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Efficacy and tolerability of a combination of Lyprinol® and high concentrations of EPA and DHA in inflammatory rheumatoid disorders

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Abstract

This 12-week drug-monitoring study was conducted to evaluate the efficacy of Sanhelios Mussel Lyprinol® Lipid Complex on 50 adult men and women with inflammatory rheumatoid arthritis. A total of 34 patients required drug therapy before and during the study. By the end of the study, 21 (62%) patients were able to reduce their dosage and 13 were able to terminate drug therapy. At the end of the treatment period, 38% were regarded symptom free, and the number of patients with severe pain decreased significantly from 60% at baseline to 25% at the completion of the trial. A significant effect was observed for each investigated parameter. The special combination of Lyprinol and omega-3 fatty acids was generally very well tolerated, with only one, nonserious adverse event (mild nausea) reported. This dietary supplement may therefore be considered an effective and well-tolerated component of treatment regimens for inflammatory rheumatoid arthritis.

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References

  1. Klemm C. Clinical experience with an anti-rheumatic ointment treatment (Extendon-ointment) [in German].Z Allgemeinmed. 1973;49:1049–1052.

    PubMed  CAS  Google Scholar 

  2. Curtis CL, Hughes CE, Flannery CR, Little CB, Harwood JL, Caterson B. N-3 fatty acids specifically modulate catabolic factors involved in articular cartilage degradation.J Biol Chem. 2000; 275:721–724.

    Article  PubMed  CAS  Google Scholar 

  3. Sanders TA. Marine oils: metabolic effects and role in human nutrition.Proc Nutr Soc. 1993;52: 457–472.

    Article  PubMed  CAS  Google Scholar 

  4. van der Tempel H, Tulleken JE, Limburg PC, Muskiet FA, van Rijswijk MH. Effects of fish oil supplementation in rheumatoid arthritis.Ann Rheu Dis. 1990;49:76–80.

    Article  Google Scholar 

  5. Gibson SL, Gibson RG. The treatment of arthritis with a lipid extract of Pernea canaliculus: a randomized trial.Complement Ther Med. 1999;6:122–126.

    Article  Google Scholar 

  6. Halpern GM. Anti-inflammatory effects of a stabilized lipid extract of Pernea canaliculus (Lyprinol®).Allerg Immunol (Paris). 2000;32:272–278.

    Article  CAS  Google Scholar 

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Authors and Affiliations

  1. Institute for Phytopharmaceuticals, PhytoPharm Consulting, Berlin, Germany

    Joerg Gruenwald PhD & Hans-Joachim Graubaum PhD

  2. Private Surgery Kurfuerstendamm, Berlin, Germany

    Knuth Hansen MD & Barbara Grube MD

Authors
  1. Joerg Gruenwald PhD
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  2. Hans-Joachim Graubaum PhD
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  3. Knuth Hansen MD
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  4. Barbara Grube MD
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Gruenwald, J., Graubaum, HJ., Hansen, K. et al. Efficacy and tolerability of a combination of Lyprinol® and high concentrations of EPA and DHA in inflammatory rheumatoid disorders. Adv Therapy 21, 197–201 (2004). https://doi.org/10.1007/BF02850125

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  • DOI: https://doi.org/10.1007/BF02850125

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