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Oxidation of lincomycin by hydrogen peroxide restricts its potential biotransformation with haloperoxidases

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Abstract

Lincomycin biotransformation was conducted by usingStreptomyces venezuelae andStreptomyces phaeochromogenes cell-free extracts. Reaction products were isolated and identified by MS and NMR spectroscopy as lincomycin sulfoxide and lincomycin sulfone. Both compounds arise also by chemical oxidation with hydrogen peroxide; this reaction represents a new efficient way for the preparation of lincomycin sulfoxide and lincomycin sulfone and simultaneously excludes the biotransformation of lincomycin using haloperoxidases.

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Authors and Affiliations

  1. Institute of Microbiology, Academy of Sciences of the Czech Republic, 124 20, Prague, Czechia

    S. Posíšil, P. Sedmera, P. Halada & J. Spížek

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  1. S. Posíšil
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  2. P. Sedmera
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  3. P. Halada
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  4. J. Spížek
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Correspondence to S. Posíšil.

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Posíšil, S., Sedmera, P., Halada, P. et al. Oxidation of lincomycin by hydrogen peroxide restricts its potential biotransformation with haloperoxidases. Folia Microbiol 46, 376–378 (2001). https://doi.org/10.1007/BF02814424

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  • DOI: https://doi.org/10.1007/BF02814424

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