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Toxic levels of selenium in enzymes and selenium uptake in tissues of a marine fish

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Abstract

Acute toxicity of selenium as selenite inZosterisessor ophiocephalus by ip injection was studied. The 50% lethal dose and 50% lethal time were measured to be 0.29 ppm and 96 h, respectively. Se concentrations in liver, gill, skin and muscle, and Cyt. P450 level, Se-GPx, and Total GPx enzyme activities in liver were also assessed at different doses and times after injection. Starting at 0.3 ppm injected dose, enzyme activities and Se concentration in tissues but not in muscle, showed significant differences from the control group. A threshold behavior was inferred. Normal conditions of enzyme activities and Se concentration in tissues were restored about 1 wk after injection. Biological elimination half-lives were about 2 d for liver and gill, and 5 d for skin.

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Authors and Affiliations

  1. Dipartimento di Biologia, Universitá di Padova, Padova, Italy

    Laura Tallandini, Silvia De Boni & Margherita Turchetto

  2. Dipartimento di Scienza dell’Ingegneria, Universitá di Modena, Modena, Italy

    Rodolfo Cecchi

  3. Istituto di Chimica Biologica, Universitá di Verona, Verona, Italy

    Silvio Galassini

  4. Osservatorio Geofisico, Universitá di Modena, Modena, Italy

    Grazia Ghermandi

  5. Dipartimento di Scienze Fisiche, Universitá di Napoli “Federico II”, Napoli, Italy

    Giancarlo Gialanella & Renata Moro

  6. Laboratori Nazionali dell’INFN, Legnaro (Padova), Italy

    Nianqing Liu

  7. Institute of High Energy Physics, Academia Sinica, Beijing, China

    Nianqing Liu

  8. Istituto Nazionale di Fisica Nucleare, Sezione di Napoli, Italy

    Yuanxung Zhang

  9. Shangai Institute of Nuclear Research, Shangai, China

    Yuanxung Zhang

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  1. Laura Tallandini
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  2. Rodolfo Cecchi
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  3. Silvia De Boni
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  4. Silvio Galassini
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  5. Grazia Ghermandi
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  6. Giancarlo Gialanella
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  7. Nianqing Liu
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  8. Renata Moro
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  9. Margherita Turchetto
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  10. Yuanxung Zhang
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Tallandini, L., Cecchi, R., De Boni, S. et al. Toxic levels of selenium in enzymes and selenium uptake in tissues of a marine fish. Biol Trace Elem Res 51, 97–106 (1996). https://doi.org/10.1007/BF02790152

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  • DOI: https://doi.org/10.1007/BF02790152

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