Abstract
A 68-year-old man presented with hemiparesis, lymphocytosis, and cerebral lesions on MRI. Flow cytometry of blood, bone marrow and cerebrospinal fluid showed B-CLL lymphocytes with bright CD20 expression, slg, and absence of CD23 antigen. Fluorescencein situ hybridisation showed trisomy 12 in 50% of analysed peripheral mononuclear cells. The patient died 6 months after the diagnosis. Rapidly progressive and fatal course of the disease was consistent with known bad prognostic significance of CD20 bright expression and trisomy 12.
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Poplawska-Szczyglowska, L., Walewski, J., Pienkowska-Grela, B. et al. Chronic lymphocytic leukaemia presenting with central nervous system involvement. Med Oncol 16, 65–68 (1999). https://doi.org/10.1007/BF02787361
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DOI: https://doi.org/10.1007/BF02787361