Skip to main content
SpringerLink
Log in

Zinc and insulin sensitivity

  • Part 2: Trace elements in endocrinology
  • Section 3: Diabetes and Glucose Tolerance
  • Published:
Biological Trace Element Research Aims and scope Submit manuscript

Abstract

Many studies have shown that zinc deficiency could decrease the response to insulin. In genetically diabetic animals, a low zinc status has been observed, contrary to induced diabetic animals. The zinc status of human patients depends on the type of diabetes and the age. Zinc supplementation seems to have beneficial effects on glucose homeostasis. However, the mechanism of insulin resistance secondary to zinc depletion is yet unclear. More studies are therefore necessary to document better zinc metabolism in diabetes mellitus, and the antioxidant activity of zinc on the insulin receptor and the glucose transporter.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Y. A. A. Lazaris and Z. E. Bavel'skii,Bull. Exp. Biol. Med. 77, 647 (1980).

    Google Scholar 

  2. E. R. Arquilla, S. Paker, W. Tarmas, and S. Miyamoto,Endocrinology 103, 1440 (1978).

    Article  PubMed  CAS  Google Scholar 

  3. A. S. E. Levine, C. J. Mc Clain, B. S. Handwerger, D. M. Brown, and J. E. Morley,Am. J. Clin. Nutr. 37, 382 (1983).

    PubMed  CAS  Google Scholar 

  4. A. D. M. Oorodian and A. D. Morley,Am. J. Clin. Nutr. 45, 877 (1987).

    Google Scholar 

  5. W. B. Kinlaw, A. S. Levine, J. E. Morley, S. E. Silvis, and C. J. McClain,Am. J. Medicine 75, 273 (1982).

    Article  Google Scholar 

  6. P. Faure, A. M. Roussel, M. Osman, A. Favier, and S. Halimi,Diab. Met. in press (1991).

  7. S. Halimi, F. Assimacopoulos, J. Terretaz, and B. Jeanrenaud,Diabetologia 80, 268 (1987).

    Article  Google Scholar 

  8. B. Winterberg, M. Bochichio, T. H. Hossdonf, H. Lahl, A. E. Lison, and H. Zumkley,Trace El. Med. 6, 173 (1989).

    Google Scholar 

  9. D. G. Hendricks and A. W. Mahoney,Nut. Foad Sciences 102, 1079 (1972).

    CAS  Google Scholar 

  10. A. M. Huber, and S. Gershoff,J. Nutr. 103, 1739 (1973).

    PubMed  CAS  Google Scholar 

  11. J. H. Y. Park, J. Carter, M. H. Hart, S. U. Endman, P. Pour, and J. A. Vanderhoof,Am. Phys. Soc. 251, 273 (1986).

    Google Scholar 

  12. S. L. Howell, M. Tyhurst, H. Dubefelt, A. Anderson, and C. Hellstorm,Cell. Tiss. Res. 107, 118 (1978).

    Google Scholar 

  13. A. C. Herington,Horm. Metab. Res. 11, 853 (1985).

    CAS  Google Scholar 

  14. H. Y. Jung, G. J. Carter, and M. D. Vanderhoof,Nut. Res. 9, 183 (1989).

    Article  Google Scholar 

  15. T. J. Wheeler and P. C. Hinckle,Am. J. Phys. 47, 503 (1985).

    CAS  Google Scholar 

  16. S. K. Jaim, R. Mc Vie, J. Duett, and J. Herbst,Diabetes 38, 1539 (1989).

    Article  Google Scholar 

  17. D. V. Godim, S. A. Wahaieb, M. E. Garnett, and A. D. Goumeniouk,Biochemistry 84, 223 (1988).

    Google Scholar 

  18. N. Nath, S. N. Chari, and A. B. Rath,Diabetes 33, 586 (1984).

    Article  PubMed  CAS  Google Scholar 

  19. A. M. Michelson, K. Puget, and P. Durosay,C. R. Soc. Biol. 179, 429 (1985).

    CAS  Google Scholar 

  20. C. Coudray, M. J. Richard, F. Laporte, A. M. Roussel, and A. Favier,Clin. Chem. J. in press (1991).

  21. J. M. May and S. Contoreggi,J. Biol. Chem 257, 4362 (1981).

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Laboratoire de Biochimie C, Hôpital A. Michallon, BP 217 X, F. 38043, Grenoble Cedex, France

    Patrice Faure, Anne Roussel, Charles Coudray, Marie Jeanne Richard & Alain Favier

  2. Laboratoire de recherche métabolique Université Joseph Fourier, Domaine de la merci, F. 38700, La Tronche, France

    Serge Halimi

Authors
  1. Patrice Faure
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Anne Roussel
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Charles Coudray
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Marie Jeanne Richard
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Serge Halimi
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Alain Favier
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Faure, P., Roussel, A., Coudray, C. et al. Zinc and insulin sensitivity. Biol Trace Elem Res 32, 305–310 (1992). https://doi.org/10.1007/BF02784615

Download citation

  • Received:

  • Accepted:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF02784615

Index Entries

Search

Navigation