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Effect of caerulein administration on portal plasma somatostatin in dogs

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Summary

The effect of administration of synthetic caerulein on canine plasma somatostatin concentration in the portal vein was investigated using specific radioimmunoassay of acid-acetone extracted plasma. Gel chromatography revealed that the main component of the plasma somatostatin in the portal vein was identical with somatostatin-14. After administration of caerulein (5ng/kg), the somatostatin level increased significantly while the gastrin level remained unchanged. These results suggested that caerulein affects D cell function but not gastrin secretion.

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Authors and Affiliations

  1. 2nd Department of Internal Medicine, Chiba University School of Medicine, 81 Inohana 1-chome, 280, Chiba City, Japan

    Junji Kasanuki M.D., Shigeru Fujimoto M.D., Hideichi Marino M.D., Azuma Kanatsuka M.D., Terue Imaizumi M.D., Hideaki Koseki M.D., Ryoichi Kaneko M.D., Yoshitaka Tokumasa M.D. & Sho Yoshida M.D.

  2. First Department of Surgery, Chiba University School of Medicine, 280, Chiba

    Shigeru Fujimoto M.D.

Authors
  1. Junji Kasanuki M.D.
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  2. Shigeru Fujimoto M.D.
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  3. Hideichi Marino M.D.
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  4. Azuma Kanatsuka M.D.
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  5. Terue Imaizumi M.D.
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  6. Hideaki Koseki M.D.
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  7. Ryoichi Kaneko M.D.
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  8. Yoshitaka Tokumasa M.D.
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  9. Sho Yoshida M.D.
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Kasanuki, J., Fujimoto, S., Marino, H. et al. Effect of caerulein administration on portal plasma somatostatin in dogs. Gastroenterol Jpn 19, 221–226 (1984). https://doi.org/10.1007/BF02779173

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  • DOI: https://doi.org/10.1007/BF02779173

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