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Guillain-barré syndrome associated with acute hepatitis a

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Summary

A case of Guillain-Barré syndrome in a 49-year-old male is described. The syndrome presented as tetraplegia with sensory impairment and the pre-icteric phase of acute hepatitis A. Both viral hepatitis and neurologic disturbances improved, although neurologic changes lasted for 3 months after the onset. HA IgM antibody in cerebrospinal fluid was first manifest with onset of neurologic symptoms. On the basis of this finding and some reports in the literature it seems possible that the Guillain-Barré syndrome may be related to the immunopathogenetic mechanism of hepatitis A virus infection.

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Authors and Affiliations

  1. Liver Unit, Department of Medicine, Juntendo University School of Medicine, 1-1 Hongo 2 chome, Bunkyo-ku, 113, Tokyo, Japan

    Masahito Igarashi M.D., Masahiro Tomono M.D., Shigeyuki Uchida M.D., Yuji Yamashiro M.D. & Toshihiko Namihisa M.D.

  2. Department of Neurology, Juntendo University School of Medicine, Hongo, Tokyo, Japan

    Shigeki Tanaka M.D.

Authors
  1. Masahito Igarashi M.D.
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  2. Masahiro Tomono M.D.
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  3. Shigeyuki Uchida M.D.
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  4. Yuji Yamashiro M.D.
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  5. Toshihiko Namihisa M.D.
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  6. Shigeki Tanaka M.D.
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Igarashi, M., Tomono, M., Uchida, S. et al. Guillain-barré syndrome associated with acute hepatitis a. Gastroenterol Jpn 18, 549–552 (1983). https://doi.org/10.1007/BF02774695

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  • DOI: https://doi.org/10.1007/BF02774695

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