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Etiology of cholesterol gallstones

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Summary

Formation of pure cholesterol stones is initiated by an excessive intake of highly purified carbohydrates, a large intake of animal fats and a restricted intake of vegetable fibers.

When the protein content of the lithogenic diet was reduced, mixed or combined stones were formed in golden hamsters. These experimentally, dietarily produced gallstones had compositions and fine structures similar to those of human gallstones.

Some mentions were made on black stones which were found in the aged golden hamsters fed with lithogenic diets.

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Authors and Affiliations

  1. 2nd Department of Surgery, Faculty of Medicine, Kyoto University, Kawara-machi 54, Shogoin, Sakyo-ku, 606, Kyoto, Japan

    Masao Nagase M.D., Yorinori Hikasa M.D., Hiroshi Tanimura M.D., Motoichi Setoyama M.D., Toshio Kamata M.D., Sumio Mukaihara M.D. & Keisuke Maruyama M.D.

Authors
  1. Masao Nagase M.D.
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  2. Yorinori Hikasa M.D.
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  3. Hiroshi Tanimura M.D.
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  4. Motoichi Setoyama M.D.
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  5. Toshio Kamata M.D.
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  6. Sumio Mukaihara M.D.
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  7. Keisuke Maruyama M.D.
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Additional information

This work was supported by Grant In Aid for Scientific Research of The Japanese Ministry of Education No. 244050, 1977.

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Nagase, M., Hikasa, Y., Tanimura, H. et al. Etiology of cholesterol gallstones. Gastroenterol Jpn 14, 40–47 (1979). https://doi.org/10.1007/BF02774603

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  • DOI: https://doi.org/10.1007/BF02774603

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