Summary
In 5 patients with diverticular disease, colonie motilities of the proximal and distal colon were recorded using the ERBI method. The motilities were studied during resting, after prostigmin 0.5mg i.m. injection and after prifinium bromide 7.5mg i.m. injection, with the following results: After prostigmin colonie motility of the proximal colon became significantly greater than that of the distal colon. Prifinium bromide inhibited the prostigmin-induced hypermotility markedly. It was demonstrated that this drug has an anti-spasmodic action not only on the distal colon but also on the proximal colon. Prifinium bromide was an anti-spasmodic drug which brought about a rapid effect which appears within 3 minutes after injection. The effect persisted for about 1 hour.
Similar content being viewed by others
References
Kihara T, Ishihara Y, Ohta A: The effect of prifinium bromide (1, l-diethyl-3-(diphenylmethylene)-2-methylpyrrolidium bromide) on the gastric antrat motility in man. Arzneim Forsch 20: 762–767, 1970
Kawai A, Nakagami Y: Effect of prifinium bromide on urolithiasis and cystitis in urology. Asian Med J 11: 27–37, 1968
Fink S, Friedman G: The different effect of drugs on the proximal and distal colon. Am J Med 28: 534–540, 1969
Chauve A, Devroede G, Bastin E: Intraluminal pressures during perfusion of the human colon in situ. Gastroenterology70: 336–340, 1976
Farrar JT, Bernstein JS: Recording of intraluminal gastrointestinal pressures by a radiotelemetering capsule. Gastroenterology 35: 603–612, 1957
Misiewicz JJ, Connell AM, Pontes FA: Comparison of the effect of meals and prostigmin on the proximal and distal colon in patients with and without diarrhea. Gut 7: 468–473, 1966
Wangel AG, Deller DJ: Intestinal motility in man III. Mechanisms of constipation and diarrhea with particular reference to the irritable colon syndrome. Gastroenterology 48: 69–84, 1965
Painter NS, Burkitt DP: Diverticular disease of the colon, a 20th century problem. Clinics in Gastroenterology 4: 3–22, 1975
Srivastava GS, Smith AN, Painter NS: Sterculia bulkfoming agent with smooth-muscle relaxant versus bran in diverticular disease. Brit Med J 1: 315–318, 1976
Parks TG: Natural history of diverticular disease of the colon. Clinics in Gastroenterology 4: 53–68, 1975
Kern F Jr, Almy TP: The effects of acetylcholine and methacholine upon the human colon. J Clin Invest 31: 555–560, 1952
Holdstock DJ, Misiewicz JJ, Waller SL: Observation on the mechanism of abdominal pain. Gut 10: 19–31, 1969
Sasaki D, Higuchi K, Munakata A, Kawakami K, Yoshida Y: Motility studies of proximal and distal colon, with special reference to the diverticular disease of the right-sided colon and the irritable colon syndrome. Hepato-Gastroenterology Supple. Abstracts of the XI International Congress of Gastroenterology, A.S.N.E.M.G.E. 252, 1980
Painter NS, Truelove SC: The intraluminal pressure patterns in diverticulosis of the colon. Part I Resting patterns of pressure. Gut5: 201–213, 1964
Arfwidsson S, Kock NG: Intraluminal pressure in the sigmoid colon of normal subjects and patients with diverticular disease of the colon. Acta Chir Scand Supple 342: 11–26, 1964
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Sasaki, D., Munakata, A., Saitoh, Y. et al. Anti-spasmodic effect of prifinium bromide on the proximal and distal colon in patients with diverticular disease. Gastroenterol Jpn 16, 344–349 (1981). https://doi.org/10.1007/BF02774466
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF02774466