Summary
The existence of tissue-bound lithocholate in liver tissue was first suggested by Nair et al. (Lipids 1988;12:922–929). Since lithocholate is well known to be cholestatic, we investigated whether tissue-bound lithocholate, if present, can be correlated to liver dysfunction in obstructive jaundice. Tissue-bound lithocholate in liver tissues of 7 patients with obstructive jaundice was analyzed using gas chromatography-mass spectrometry-selected ion monitoring. We found no accumulation of lithocholate, including tissue-bound form, indicating that the role of lithocholate in inducing hapatic dysfunction in obstructive jaundice is minimal, if any.
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References
Fisher MM, Magnusson R, Miyai K: Bile acid metabolism in mammals. I.Bile acid induced intrahepatic cholestasis. Lab Invest 1971;25: 88–91
Miyai K, Richardson AL, Mayer W, et al: subcellular pathway of rat liver in cholestasis and choleresis induced by bile salts. (1) Effects of lithocholic, 3β-hydroxy-5-cholenoic, cholic and dehydrocholic acids. Lab Invest 1977;36: 249–258
Kakis G, Yousef IM: Mechanism of cholic acid protection in lithocholate-induced intrahepatic cholestasis in rats. Gastroenterology 1980;78: 1402–1411
Mathis U, Karlaganis G, Preisig R: Monohydroxy bile salt sulfates: Tauro-3β-hydroxy-5-cholenoate-3-sulfate induces intrahepatic cholestasis in rats. Gastroenterology 1983;85: 674–681
Oelberg DG, Chari MV, Little JM, et al: Lithocholate glucuronide is a cholestatic agent. J Clin Invest 1984;73: 1507–1514
Nair PP, Mendeloff AI, Vocci M, et al: Lithocholic acid in human liver:identification of ε-lithocholyl lysine in tissue protein. Lipids 1977;12: 922–929
Nair PP, Solomon, R, Bankoski J, et al: Bile acids in tissues: binding of lithocholic acid to protein. Lipids 1978; 13: 966–970
Turjiman N, Nair PP: Nature of tissue bound lithocholic acid and its implication in the role of bile acids in carcinogenesis. Cancer Res 1981;41: 3761–3763
Yanagisawa J, Akashi Y, Miyazaki H, et al: Critical evaluation of the existence of so-called tissue-bound lithocholate in human liver tissue by selected ion monitoring. J Lipid Res 1984;25: 1263–1271
Yanagisawa J, Itoh M, Ishibashi M, et al: Microanalysis of bile acid in human liver tissue by selected ion monitoring. Anal Biochem 1980;104: 75–86
Schaffner F, Popper H: Structure of the liver. In: Berk JE et al eds. Bockus Gastroenterology 5th ed. W.B.Sanders Company, Philadelphia. 1985;2626
Akashi Y, Miyazaki H, Nakayama F: Correlation of bile acid composition between liver tissue and bile. Clin Chim Acta 1983;133: 125–132
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Yanagisawa, J., Nagai, M., Hirano, Y. et al. Lithocholate in liver tissue with obstructive jaundice. Gastroenterol Jpn 24, 156–158 (1989). https://doi.org/10.1007/BF02774190
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DOI: https://doi.org/10.1007/BF02774190