Abstract
We describe herein a case of inverted papilloma of the ureter, in which transitional cell carcinoma of the bladder developed twenty-three months after nephroureterectomy. Flow cytometric analysis of formalin-fixed and paraffin-embedded archival material of the inverted papilloma revealed DNA aneuploidy pattern and relatively high percentage of S phase. Retrospectively, DNA measurement thus provided the predictive value regarding biological activity and the clinical behaviour of the present case.
Similar content being viewed by others
References
Henderson, D. W., Allen, P. W., Bourne, A. J.: Inverted urinary papilloma.Virchows Arch. A. Pathol. Anat. Histol., 366, 177 (1975).
Cameron, K. M., Lupton, C. H.: Inverted papilloma of the lower urinary tract.Br. J. Urol., 48, 567 (1976).
Lazarevic, B., Garret, R.: Inverted papilloma and papillary transitional cell carcinoma of urinary bladder.Cancer, 42, 1904 (1978).
Whitesel, J. A.: Inverted papilloma of the urinary tract: Malignant potential.J. Urol., 127, 539 (1982).
Hedley, D. W., Friedlander, M. L., Taylor, I. W., Rugg, C. A., Musgrove, E. A.: Method for analysis of cellular DNA content of paraffin-embedded pathological material using flow cytometry.J. Histochem. Cytochem., 31, 1333 (1983).
Vindelov, L. L., Christensen, I. J., Nissen, N. I.: A detergent-trypsin method for the preparation of nuclei for flow cytometric DNA analysis.J. Cell. Biol., 60, 523 (1974).
Frankfurt, O. S., Greco, W. R., Slocum, H. K., Arbuck, S. A., Gamarra, M., Pavelic, Z. P., Rustum, Y. M.: Proliferative characteristics of primary and metastatic human solid tumors by DNA flow cytometry.Cytometry, 5, 629 (1984).
Potts, I. F., Hirst, E.: Inverted papilloma of the bladder.J. Urol., 90, 175 (1963).
Kunze, E., Schauer, A., Schmitt, M.: Histology and histopathogenesis of two different types of inverted urothelial papillomas.Cancer, 51, 348 (1983).
Altaffer, L. F., Wilkerson, S. Y., Jordan, G. H., Lynch, D. F.: Malignant inverted papilloma and carcinoma in situ of the bladder.J. Urol., 128, 816 (1982).
Stein, B. S., Rosen, S., Kendall, A. R.: The association of inverted papilloma and transitional cell carcinoma of the urothelium.J. Urol., 131, 751 (1984).
Fromowitz, F. B., Steinbook, M. L., Lautin, E. M., Friedman, A. C., Kahan, N., Bennett, M. J., Koss, L. G.: Inverted papilloma of the ureter.J. Urol., 126, 113 (1981).
Alroy, J., Miller, A. W., Coon, J. S., James, K. K., Gould, V. E.: Inverted papilloma of the urinary bladder. Ultrastructural and immunologic studies.Cancer, 46, 64 (1980).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Kunimi, K., Uchibayashi, T. & Egawa, M. A case of inverted papilloma of the ureter: Is the DNA ploidy pattern associated with occurrence of transitional cell carcinoma of the bladder?. International Urology and Nephrology 26, 17–22 (1994). https://doi.org/10.1007/BF02768239
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF02768239