Abstract
The study covers 78 children with typhoid fever who were hospitalized in April & May 1990. Serious complications were present in 32% (toxemia 22%, ileus 25% and myocarditis 8%). Blood cultures were positive in 30 of 49 tested. Others were diagnosed by positive Widal test.In vitro cultures ofS. typhi were resistant to chloramphenicol (90%), ampicillin (93%) and co-trimoxazole (97%). However all were highly sensitive to ciprofloxacin and moderately sensitive to cephalexin and gentamycin. Ciprofloxacin alone or in combination was given in 73 of the 78 children and found to be remarkably effective in controlling the disease and preventing relapse. No serious side effects were noted. The cohort is being followed up for possible long term adverse effects.
Similar content being viewed by others
References
Jain S, Chitnis DS, Shain A et al. Outbreak of chloromphenicol resistant typhoid fever.Indian Pediatr 1987; 24: 193–197.
Banerjee KS, Chaturvedi P, Narang P. Enteric fever in rural Maharashtrian children. Abstract of papers presented at XXVIINational Conference of IAP, Bangalore, June, 1990, pp 138.
Nande A, Pattnaik AK. Ciprofloxacin in Chloromycetin resistant enteric fever. Abstract of papers presented at XXVIINational Conference of IAP, Bangalore, June 1990, pp 33.
Chandra J, Marwah RK, Sachdeva S. Chloramphenicol resistantS. typhi—Therapeutic considerations.Indian J Pediatr 1984; 51: 567–570.
Kapse A. Ciprofloxacin in pediatric enteric fever. Abstract of papers presented at the XXVIINational Conference of IAP, Bangalore, June, 1990, pp 138.
Arcieri G, Griffith E, Gsuenwaldt G et al. Ciprofloxacin—An update on clinical experience.Am J Med 1987; 82 (Supplement 4A): 381–386.
Schluter G. Toxicology of ciprofloxacin. Proceedings of the 1st International Ciprofloxacin Workshop at Amsterdam. Neu MC & Weuta H (Ed),Excerpta Medica 1986; 1: 61–67.
Schluter G. Ciprofloxacin-Review of potential toxicologic effects.Am J Med 1987; 82 (Supplement 4A): 91–94.
Neu HC. Quinolones: A new class of antimicrobial agents with wide potential uses.Med Clin North Am 1988; 72: 623–636.
Bannon KJ, Stutchfield PR, Weinaling AM, Damjanovic V. Ciprofloxacin in neonatal enterobacter cloacae septicaemia.Arch Dis Child 1989; 64: 1388–1391.
Steele RW, Kearns GL. Antimicrobial therapy for pediatric patients.Pediatr Clin North Am 1989; 36: 1321–1349.
McQueen C, William G. Effects of quinolone antibiotics in tests for genotoxicity.Am J Med 1987; 82 (Supplement 4A): 94–96.
Garlando F, Tauber MG, Joss B et al. Ciprofloxacin-induced haematuria.Infection 1985; 13: 177–178.
Feigin RD. Infectious Diseases. Infections due to Salmonellae. In: Nelson WE, Vaughan BC, Behram RE, (Eds),Nelson's Textbook of Pediatrics, Philadelphia: W.B. Saunders Company, 1987; 602–603.
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Bavdekar, A., Chaudhari, M., Bhave, S. et al. Ciprofloxacin in typhoid fever. Indian J Pediatr 58, 335–339 (1991). https://doi.org/10.1007/BF02754962
Published:
Issue Date:
DOI: https://doi.org/10.1007/BF02754962