References
Beck SW. Erythrocyte disorders-anemias related to disturbance of DNA synthesis (megaloblastic anemias) In: William J Williams, Beutler E, Ersley AJ, Lichtman MA eds.Haematology 3rd edn. McGraw-Hill Book company 1983; 436–465
Herbert V. Megaloblastic anaemias.Lab Invest 1985;52:3–19
Killmann SA. Effects of deoxyuridine on incorporation of tritiated thymidine. Difference between normoblasts and megaloblasts.Acta Med Scand 1964;175:483–488
Beck SW. Metabolic features of cobalmin deficiency in man. InCobalmins: Biochemistry and pathophysiology ed. BM Babior Wiley-interscience. New York 1975 p 403
Hoffbrand AV, Wickremasinghe RG. Megaloblastic anaemia. In: Hoffbrand AV, ed.Recent advances in haematology. No. three Churchill Livingstone. The Pitman Press, Bath, 1982:25–44
Taheri R, Wickremasinghe RG, Hoffbrand AV. Alternative metabolic fates of thymine nucleotides in human cells.Biochem J 1981;194:451–461
William SB. Megaloblastic anaemia in CecilTextbook of medicine. James B, Wynaggarden & Lloyd H Smith JR ed. Philadelphia: W.B. Saunders Company 1985; 893–899
Scott JM, Dinn JJ, Wilson P, Weir DG. Pathogenesis of subacute combined degeneration: a result of methyl group deficiency.Lancet 1981;2:334–337
Chanarin I.The megaloblastic anaemias 2nd ed. Oxford: Blackwell 1979.
Grasbeck R. Calculations on vitamin B12 turnover in man.Scand J Clin Lab Invest 1959;11:250–258
Saraya AK, Choudhry VP, Ghai OP. Interrelationships of vitamin B12, folic acid and iron in anaemia of infancy and childhood: effects of vitamin B12 and iron therapy of folate metabolism.Am J Clin Nutr 1973;26:640–646
Saraya AK, Singla PN, Ghai OP, Ramchandran K. Nutritional Macrocytic anaemia of infancy & childhood.Am J Clin Nutr 1970;23:1378–1384
Saraya AK, Choudhary VP, Ghai OP. Relative roles of iron, vitamin B12 and folic acid deficiency in macrocytic anaemia in, infancy and childhood.J AIIMS 1977;3:65–72
Saraya AK.Nutritional Anemia. In: Ahuja MMS ed.Progress in Clinnical Medicine in India. Second series. New Delhi, Arnold Heinemann 1978:534–569
Brugg WR, Goff JS, Allen NG, Podell ER, Allen RH. Development of a dual label schilling test for pancreatic exocrine function based on the differential absorption of cobalmin bound to intrinsic factor and R protein.Gastroenterology 1980;78:937–949
Allen RH, Seetharam B, Allen NC, Podell ER, Alpers DH. Correction of cobalamin malabsorption in pancreatic insufficiency with a cobalamin analogue that binds with high affinity to R protein but not to intrinsic factor.J Clin Invest 1978;61:1628–1634
Herzlich B, Herbert V. The role of pancreas in cobalamin (Vitamin B12) absorption.Am J Gastroenterol 1984;79:489–493
Kanazawa S, Herzlich B, Herbert V. Enhancing effect of human bile on the uptake of free vitamin B12 and intrinsic factor-B12 by receptors on the small bowel epithelial-cells (abstr.).Blood 1982;60 (Suppl. I):309
Jacob E, Baker SJ, Herbert V. Vitamin B12 binding proteins.Physiol Rev 1980;60:918–960
Kanazawa S, Herbert V, Herzlick B, Drivas G, Manusselis C. Removal of cobalmin analogue in bile by enterohepatic circulation of vitamin B12.Lancet 1983;1:707–708
Chanarin I, Malkowska V, Marie O'Hea A, Rinsler MG, Price AB. Megaloblastic anaemia in a vegetarian Hindu community.Lancet 1985;2:1168–1172
Abdulla M, Anderson I, Asp N-Get al. Nutrient intake and health status of vegans. Chemical analysis of diets using the duplicate portion sampling technique.Am J Clin Nutr 1981;34:2464–2477
Baker SJ, Jacob E, Rajan KT, Suaminathan SP. Vitamin B12 deficiency in pregnancy and puerperium.Br Med J 1962;1:1658–1661
Jadhay M, Webb JKG, Vaishnana S, Baker SJ. Vitamin B12 deficiency in Indian infants: A clinical syndrome.Lancet 1962;2:903–907
Herbert V, Manusselis C, Drivas G, Colman N. Low Vitamin B12 content of heavily processed milk may explain vitamin B12 deficiency in young adults in Mexico (abstr).Clin Res 1983;31:241A
Baker SJ. Megaloblastic Anaemia. In: Ahuja MMS, ed.Progress in clinical medicine in India. Series First. New Delhi. Arnold Heinemann Publishers. 1981; 420–444
Mathews JH, Wood JK. Megaloblastic anaemia in vegetarian Asians.Clin Lab Haematol 1984;6:1–7
Spurling CL, Sacks MS, Jiji RM. Juvenile pernicious anemia.N Engl J Med 1964;271:995–1003
Maclean LD, Sunberg RD. Incidence of megaloblastic anemia after total gastrectomy.N Engl J Med 1956;254:885–93
Vaish SK, Sampath Kumar J, Jacob R, Baker SJ. The stomach in tropical spure.Gut 1965;6:458–465
Baker SJ. Tropical megaloblastic anaemia.Indian J Pathol Bact 1958;1:11–26
Herbert V, Jacob E, Wong KT, Scot J, Pfeffer R. Low serum vitamin B12 levels in patients receiving ascorbic acid in megadoses: Studies concerning the effect of ascorbate on radio-isotope vitamin B12 assay.Am J Clin Nutr 1978;31:253–258
Deacon R, Lumb M, Perry J, Chanarin I, et al. Selective inactivation of vitamin B12 in rats by nitrous oxide.Lancet 1978;2:1023–1024
Chanarin I. Cobalamins and nitrous oxide: A review.J Clin Pathol 1980;33:909–916
Herbert V. Experimental Nutritional folate deficiency in man.Trans Assoc Am Physns 1962;75:307–20.
Saraya AK. Interrelationship of vitamin B12, folic acid and iron in anaemia of infancy and childhood: Folate distribution and dynamics in iron deficiency. Plenary session of third meeting of the Asian-Pacific Division of Haematology Programme 1975. p 34
Pereira SM, Baker SJ. Haematologic studies in kwashiorkar.Am J Clin Nutr 1966;18:413–420
Colman N, Hettiarachchy N, Herbert V. Detection of a milk factor that facilitates folate uptake by intestinal cells.Science 1981;211:1427–1429
Poncz M, Colman N, Hert V et al. Therapy of congenital folate malabsorption.J Pediatr 1981;98:76–79
Baker SJ, Mathen VI. Tropical sprue in southern India. InTropical spure—A Wellcome Trust Collaborative Study. Churchill, London 1971
Jeejeebhoy KN, Desai HG, Borker AV et al. Tropical malabsorption syndrome in West India.Am J Clin Nutr 1968;21:994–1006
Butterworth CE. Tropical sprue: A consideration of some possible aetiological mechanisms in malabsorption, edited by R.H. Girdwood and A.N. Smith.Pfizer Medical Monograph 4 Edingburg: University of Edinburgh Press, 1969 p 238
Willoughby ML. An investigation of folic acid requirements in pregnancy. II.Br J Haemat 1967;13:503–509
Yusufji D, Mathan UI, Baker SJ. Iron, folate and vitamin B12 nutrition in pregnancy: A study of 1000 women from southern India.Bull Wld Hlth Org 1973;48:15–22
Benjamin F, Bassen FA, Mayer LM. Serum levels of folic acid vitamin B12 and iron in anaemia of pregnancy.Am J Obstet Gynec 1966;96:310–315
Ball EW, Giles C. Folic acid and vitamin B12 levels in pregnancy and their relation to megaloblastic anemia.J Clin Pathol 1964;17:165–174
Whiteside MG, Ungar B, Cowling DC. Iron, folic acid and vitamin B12 levels in normal pregnancy and their influences on birth weight and duration of pregnancy.Med J Aust 1968;1:338–342
Streiff RR, Little AB. Folic acid deficiency in pregnancy.N Engl J Med 1967;276:776–779
Tylden E. Tropical macrocytic anemia.Lancet 1986;1:94–95
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Saraya, A.K., Gupta, M.K. Megaloblastic anemia—etiology and management. Indian J Pediatr 54, 343–353 (1987). https://doi.org/10.1007/BF02748918
Issue Date:
DOI: https://doi.org/10.1007/BF02748918