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β-adrenergic receptor desensitization in cardiac hypertrophy and heart failure

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Conclusion

Based on our recent data (37,54,56) and the association that profound alterations in βAR signaling are found in chronic end-stage human heart failure (64), it is possible that defects in this pathway are primary elements that underlie the transition from compensated to decompensated cardiac failure. Decreasing the level of myocardial βARK1 in established heart failure, is a novel approach to improving impaired βAR receptor function and potentially alter the pathogenesis in this disease.

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Authors and Affiliations

  1. Department of Medicine, University of North Carolina at Chapel Hill, 27599, Chapel Hill, NC

    Dong-Ju Choi & Howard A. Rockman

  2. Department of Medicine and Cardiovascular Research Institute, Gyeong-Sang National University, Chinju, Korea

    Dong-Ju Choi

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  1. Dong-Ju Choi
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Choi, DJ., Rockman, H.A. β-adrenergic receptor desensitization in cardiac hypertrophy and heart failure. Cell Biochem Biophys 31, 321–329 (1999). https://doi.org/10.1007/BF02738246

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