Summary
Plasma concentrations of fibronectin were studied in 152 diabetics (77 males, 75 females), divided according to their hypoglycemic treatment, and in 60 normal subjects (30 males, 30 females) closely matched for age. In both sexes no significant difference of plasma fibronectin (PF) levels was observed between controls and treated groups. In the whole group of diabetics PF levels were weakly correlated with age (r=0.16; p<0.05) and not associated with HbA1 or duration of illness. Both male and female diabetics, either on sulfonylureas or insulin, with retinopathy (background, except for 2 proliferative in the group of insulin-requiring females) were characterized by significantly higher PF concentrations than either controls or patients without retinopathy.
Similar content being viewed by others
References
Barnes A. J., Locke P., Scudder P. R., Dormandy T. L., Dormandy J. A., Slack J.: Is hyperviscosity a treatable component of diabetic microcirculatory disease? — Lancetii, 789, 1977.
Bartolomei G., Seghieri G., De Giorgio L. A., Gironi A., Chisci C., Niccolai M., Mammini P.: Plasma fibronectin in diabetes. In:Belfiore F., Galton D. J., Reaven G. M. (Eds): Diabetes mellitus: etiopathogenesis and metabolic aspects. S. Karger, Basel, 1984; p. 269.
Bensoussan D., Levy-Toledano S., Passa P., Caen J., Canivet J.: Platelet hyperaggregation and increased plasma level of von Willebrand factor in diabetics with retinopathy — Diabetologia11, 307, 1975.
Chen A. B., Mosesson M. W., Solish G. I.: Identification of the cold-insoluble globulin of plasma in amniotic fluid — Amer. J. Obstetr. Gynecol.125, 958, 1976.
Clark R. A. F., Qinn J. H., Winn H. J., Lanigan J. M., Dellepella P., Colvin R. B.: Fibronectin is produced by blood vessels in responses to injury — J. exp. Med.156, 646, 1982.
Davis T. M. E.: Plasma fibronectin concentrations in diabetes and the effect of short-term, improved glucose control — Diabetologia21, 262, 1981.
Dornan T. L., Carter R. D., Bron A. J., Turner R. C., Mann J. I.: Low density lipoprotein cholesterol: an association with the severity of diabetic retinopathy — Diabetologia22, 167, 1982.
Eriksen H. O., Clemmensen I., Hansen M. S., Ibsen K. K.: Plasma fibronectin concentration in normal subjects — Scand. J. clin. Lab. Invest.42, 291, 1982.
Gensini G. F., Abbate R., Favilla S., Neri Serneri G. G.: Changes of platelet function and blood clotting in diabetes mellitus — Thrombos. Haemost.42, 983, 1979.
Heath H., Brigden W. D., Canever J. V., Pollock J., Hunter P. R., Kelsey J., Bloom A.: Platelet adhesiveness and aggregation in relation to diabetic retinopathy — Diabetologia7, 308, 1971.
Jaffe E. A., Mosher D. F.: Synthesis of fibronectin by cultured human endothelial cells — J. exp. Med.147, 1779, 1978.
Koteliansky V. E., Leytin V. L., Sviridov D. D., Repin V. S., Smirnov V. N.: Human plasma fibronectin promotes the adhesion and spreading of platelets on surfaces coated with fibrillar collagen — FEBS Letters123, 59, 1981.
Kuusela P., Vaheri A., Palo J., Ruoslahti E.: Demonstration of fibronectin in human cerebrospinal fluid — J. Lab. clin. Med.92, 595, 1978.
Ledet T., Vuust J.: Arterial procollagen type I, type III, and fibronectin. Effects of diabetic serum, glucose, insulin, ketone, and growth hormone studied on rabbit aortic myomedial cell cultures — Diabetes29, 964, 1980.
Little H. L.: Pathogenesis. Blood rheology. In:L’Esperance F. A. Jr.,James W. A. Jr. (Eds): Diabetic retinopathy. Clinical evaluation and management. C.V. Mosby Co., St Louis-Toronto-London, 1981; p. 58.
Lundbaeck K.: Growth hormone’s role in diabetic microangiopathy — Diabetes25 (Suppl. 2), 845, 1976.
Maneschi F., Mashiter K., Kohner E. M.: Insulin resistance and insulin deficiency in diabetic retinopathy of non-insulin-dependent diabetes — Diabetes32, 82, 1983.
McMillan D. E.: Disturbance of serum viscosity in diabetes mellitus — J. clin. Invest.53, 1071, 1974.
Mosesson M. W., Amrani D. L.: The structure and biologic activities of plasma fibronectin — Blood56, 145, 1980.
Mosesson M. W., Umfleet R. A.: The cold-insoluble globulin of human plasma. I. Purification, primary characterization and relationship to fibrinogen and other cold-insoluble fraction components — J. biol. Chem.245, 5728, 1970.
Mosher D. F., Williams E. M.: Fibronectin concentration is decreased in plasma of severely ill patients with disseminated intravascular coagulation — J. Lab. clin. Med.91, 729, 1978.
Owens M. R., Cimino C. D.: Synthesis of fibronectin by the isolated perfused rat liver — Blood59, 1305, 1982.
Pozza G., Cordaro C., Carandente O., Margonato A.: Study on relationship between erythrocyte filtration and other risk factors in diabetic angiopathy — La Ricerca Clin. Lab.11 (Suppl. 1), 317, 1981.
Preston F. E., Ward J. D., Marcola B. M., Porter N. R., Timperley W. R., O’Malley B. C.: Elevated beta-thromboglobulin levels and circulating platelet aggregates in diabetic microangiopathy — Lanceti, 238, 1978.
Rampling M. W., Sirs J. A.: The interactions of fibrinogen and dextrans with erythrocytes — J. Physiol. (Lond.)223, 199, 1972.
Saba T., Jaffe E.: Plasma fibronectin (opsonic glycoprotein): its synthesis by vascular endothelial cells and role in cardiopulmonary integrity after trauma as related to reticuloendothelial function — Amer. J. Med.68, 577, 1980.
Schmid-Schönbein H.: Blood rheology and physiology of microcirculation — La Ricerca Clin. Lab.11 (Suppl. I), 13, 1981.
Stathakis N. E., Fountas A., Tsianos E.: Plasma fibronectin in normal subjects and in various disease states — J. clin. Pathol.34, 504, 1981.
Author information
Authors and Affiliations
Additional information
Presented in part at the 19th Annual Meeting of the European Association for the Study of Diabetes, Oslo, 14–17 September 1983, and published in abstract form in Diabetologia25, 193, 1983.
Rights and permissions
About this article
Cite this article
De Giorgio, L.A., Seghieri, G., Gironi, A. et al. Raised plasma fibronectin concentration is related to the presence of diabetic retinopathy. Acta diabet. lat 21, 251–256 (1984). https://doi.org/10.1007/BF02642898
Received:
Issue Date:
DOI: https://doi.org/10.1007/BF02642898