Abstract
Platelet number, mean platelet volume (MPV), and platelet mass were compared among horses, foals, ponies, dogs, cats, cows, calves and goats. Platelet mass was not constant across species lines and an inverse relationship between platelet number and size was not found in all species. Although platelet mass is a function of platelet number and platelet size, these variables are likely under separate control. If platelet mass regulates thrombopoietin concentration in all species, then it is likely that thrombopoietin production and/or sensitivity of megakaryocytes to thrombopoietin also varies among species.
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References
Bessman JD, Williams LJ, Gilmer PR Jr (1981) Mean platelet volume. The inverse relation of platelet size and count in normal subjects, and an artifact of other particles. Am J Clin Pathol 76:289–293
Corash L, Chen HY, Levin J et al. (1987) Regulation of thrombopoiesis: effects of the degree of thrombocytopenia on megakaryocyte ploidy and platelet volume. Blood 70:177–185
Ebbe S, Boudreaux MK (1997) Relationship of megakaryocyte ploidy with platelet number and size in cats, dogs, rabbits, and mice. Comp Haematol Int
Gurney AL, Carver-Moore K, de Sauvage FJ et al. (1994) Thrombocytopenia inc-mpl-deficient mice. Science 265:1445–1447
Harker LA, Hunt P, Marzee UM et al. (1996) Regulation of platelet production and function by megakaryocyte growth and development factor in nonhuman primates. Blood 87:1833–1844
Haselton FR, Alexander JS (1992) Platelets and a platelet-released factor enhance endothelial barrier. Am J Physiol 263:L670-L678
Kaushansky K, Lok S, Holly RD et al. (1994) Promotion of megakaryocyte progenitor expansion and differentiation by the c-Mpl ligand thrombopoietin. Nature 369:568–571
Kuter DJ, Rosenberg RD (1995) The reciprocal relationship of thrombopoietin (c-Mpl Ligand) to changes in the platelet mass during busulfan-induced thrombocytopenia in the rabbit. Blood 85:2720–2730
Levin J, Bessman JD (1983) The inverse relation between platelet volume and platelet number. J Lab Clin Med 101:295–307
Lo SK, Burhop KE, Kaplan JE et al. (1988) Role of platelet in maintenance of pulmonary vascular permeability to protein. Am J Physiol 254:H763-H771
Mack C (1967) Regression curves and lines, correlation coefficient, normal bivariate distribution. In: Essentials of statistics for scientists and technologists. Plenum Press, New York, pp 121–122
Shepard JM, Moon DG, Sherman PF et al. (1989) Platelets decrease albumin permeability of pulmonary artery endothelial cell monolayers. Microvasc Res 37:256–266
von Behrens WE (1972) Evidence of phylogenetic canalisation of the circulating platelet mass in man. Thromb Diathes Haemotrh 27:159–172
Wendling F, Maraskovsky E, Debili N etal. (1994) c-Mpl ligand is a Immoral regulator of megakaryocytopoiesis. Nature 369:571–574
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Boudreaux, M.K., Ebbe, S. Comparison of platelet number, mean platelet volume and platelet mass in five mammalian species. Comparative Haematology International 8, 16–20 (1998). https://doi.org/10.1007/BF02628099
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DOI: https://doi.org/10.1007/BF02628099