References
Harris WH, Sledge CB. Total hip and total knee replacement. N Engl J Med 1990;323:725–31.
Johnson R, Green JR, Charnley J. Pulmonary embolism and its prophylaxis following the Charnley total hip replacement. Clin Orthop. 1977;127:123–32.
Coon WW. Risk factors in pulmonary embolism. Surg Gynecol Obstet. 1976;143:385–90.
Prevention of venous thrombosis and pulmonary embolism: consensus conference. JAMA 1986;256:744–9.
Russell JC. Prophylaxis of postoperative deep vein thrombosis and pulmonary embolism. Surg Gynecol Obstet. 1983;157:89–104.
Kakkar VV, Corrigan TP, Fossard DP. Prevention of fatal postoperative pulmonary embolism by low doses of heparin: an international multicentre trial. Lancet. 1975;2:45–51.
Clark C, Cotton LT. Blood flow in deep veins of the leg. Recording technique and evaluation of methods to increase flow during operation. Br J Surg. 1968;55:211–4.
Knight MTN, Dawson R. Effect of intermittent compression of the arms on deep venous thrombosis in the legs. Lancet. 1976;2:1265–7.
Gitel SN, Salvati EA, Wessler S, Robinson HJ, Worth MH. The effect of total hip replacement and general surgery on antithrombin III in relation to venous thrombosis. J Bone Joint Surg. 1979;61A:653–6.
McKenna R, Galante J, Bachman F, Wallace DL, Kaushal SP, Meredith P. Prevention of venous thromboembolism after total knee replacement by high-dose aspirin or intermittent calf and thigh compression. BMJ. 1980;280:514–7.
Scholz PM, Kinney JM, Chien S. Effects of major abdominal operations on human blood rheology. Surgery. 1975;77:351–9.
Dodds AJ, Matthews PN, Bailey MJ, Flute PT, Dormandy JA. Changes in red cell deformability following surgery. Thromb Res. 1980;18:561–5.
Sikorski JM, Hampson WG, Staddon GE. The natural history and aetiology of deep vein thrombosis after total hip replacement. J Bone Joint Surg. 1981;63B:171–7.
Hampson WGJ, Lucas HK, Harris FC, Roberts PH. Failure of low-dose heparin to prevent deep-vein thrombosis after total hip arthroplasty. Lancet. 1974;2:795–7.
Bergentz SE. Incidence of thromboembolism in association with surgical and medical diseases. Acta Chir Scand Suppl. 1988;543:10–4.
Muller R, Musikic P. Hemorheology in surgery—a review. Angiology. 1987;38:581–92.
Stamatakis JD, Kakkar VV, Lawrence D, Bentley PG, Nairn D, Ward V. Failure of aspirin to prevent postoperative deep vein thrombosis in patients undergoing total hip replacement. BMJ. 1978;1:1031.
Effect of aspirin on postoperative venous thrombosis. Report of the Steering Committee of a trial sponsored by the Medical Research Council. Lancet. 1972;2:441–5.
Harris WH, Athanasoulis CA, Waltman AC, Salzman EW. Prophylaxis of deep-vein thrombosis after total hip replacement. Dextran and external pneumatic compression compared with 1.2 or 0.3 gram of aspirin daily. J Bone Joint Surg. 1985;67A:57–62.
Collins R, Scrimgeour A, Yusuf S, Peto R. Reduction in fatal pulmonary embolism and venous thrombosis by perioperative administration of subcutaneous heparin. Overview of results of randomized trials in general, orthopedic and urologic surgery. N Engl J Med. 1988;318:1162–72.
Williams JW, Eikman EA, Greenberg SH, et al. Failure of low dose heparin to prevent pulmonary embolism after hip surgery or above the knee amputation. Ann Surg. 1978;188:468–74.
Harris WH, Salzman EW, Athanasoulis C, Waltman AC, Baum S, DeSanctis RW. Comparison of warfarin, low-molecular-weight dextran, aspirin, and subcutaneous heparin in prevention of venous thromboembolism following total hip replacement. J Bone Joint Surg. 1974;56A:1552–62.
Evarts CM, Alfidi RJ. Thromboembolism after total hip reconstruction. Failure of low doses of heparin in prevention. JAMA. 1973;225:515–6.
Evarts CM, Feil EJ. Prevention of thromboembolic disease after elective surgery of the hip. J Bone Joint Surg. 1971;53A:1271–80.
Leyvraz PF, Richard J, Bachmann F, et al. Adjusted versus fixed-dose subcutaneous heparin in the prevention of deep-vein thrombosis after total hip replacement. N Engl J Med. 1983;309:954–8.
Fernandez F, N’Guyen P, Van Ryn J, Ofosu FA, Hirsh J, Buchanan MR. Hemorrhagic doses of heparin and other glycosaminoglycans induce a platelet defect. Thromb Res. 1986;43:491–5.
Salzman EW. Low-molecular-weight heparin: is small beautiful? N Engl J Med. 1986;315:957–9.
Carter CJ, Kelton JG, Hirsh J, Cerskus A, Santos AV, Gent M. The relationship between the hemorrhagic and antithrombotic properties of low molecular weight heparin in rabbits. Blood. 1982;59:1239–45.
Ockelford PA, Carter CJ, Cerskus A, Smith CA, Hirsh J. Comparison of the in vivo hemorrhagic and antithrombotic effects of a low antithrombin III affinity heparin fraction. Thromb Res. 1982;27:679–90.
Kakkar VV, Murray WJG. Efficacy and safety of low-molecular-weight heparin (CY216) in preventing postoperative venous thromboembolism: a co-operative study. Br J Surg. 1985;72:786–91.
Turpie AGG, Levine MN, Hirsh J, et al. A randomized controlled trial of a low-molecular-weight heparin (Enoxaparin) to prevent deep-vein thrombosis in patients undergoing elective hip surgery. N Engl J Med. 1986;315:925–9.
Planes A, Vochelle N, Mazas F, et al. Prevention of postoperative venous thrombosis: a randomized trial comparing unfractionated heparin with low molecular weight heparin in patients undergoing total hip replacement. Thromb Haemost. 1988;60:407–10.
Levine MN, Hirsh J, Gent M, et al. Prevention of deep vein thrombosis after elective hip surgery. A randomized trial comparing low molecular weight heparin with standard unfractionated heparin. Ann Intern Med. 1991;114:545–51.
Collins GJ, Bergentz SE. Dextrans. In: Collins GJ (ed). Vascular occlusive disorders. Medical and surgical management. Mount Kisco, NY: Futura Publishing Company, 1981;393–419.
Ljungstrom KG. The antithrombotic efficacy of dextran. Acta Chir Scand Suppl. 1988;543:26–30.
Bergqvist D. Prevention of postoperative thromboembolism in Sweden—the development of practice during five years. Thromb Haemost. 1985;53:239–41.
Barber HM, Galasko CSB, Sutton RA, et al. A comparative study of dextran-70, warfarin and low-dose heparin for the prophylaxis of thrombo-embolism following total hip replacement. Postgrad Med J. 1977;53:130–3.
Bergqvist D, Efsing HO, Hallbook T, Hedlund T. Thromboembolism after elective and post-traumatic hip surgery—a controlled prophylactic trial with dextra 70 and low-dose heparin. Acta Chir Scand. 1979;145:213–8.
Neu LT, Waterfield JR, Ash CJ. Prophylactic anticoagulant therapy in the orthopedic patient. Ann Intern Med. 1965;62:463–7.
Harris WH, Salzman EW, DeSanctis RW. The prevention of thromboembolic disease by prophylactic anticoagulation. A controlled study in elective hip surgery. J Bone Joint Surg. 1967;49A:81–9.
Coventry MB, Nolan DR, Beckenbaugh RD. “Delayed” prophylactic anticoagulation: a study of results and complications in 2,012 total hip arthroplasties. J Bone Joint Surg. 1973;55-A:1487–92.
Bergqvist D. Oral anticoagulants for prophylaxis against postoperative thromboembolism. Acta Chir Scand Suppl. 1988;543:43–7.
Francis CW, Marder VJ, Evarts CM, Yaukoolbodi S. Two-step warfarin therapy. Prevention of postoperative venous thrombosis without excessive bleeding. JAMA. 1983;249:374–8.
Hull R, Hirsh J, Jay R, et al. Different intensities of oral anticoagulant therapy in the treatment of proximal-vein thrombosis. N Engl J Med. 1982;307:1676–81.
Paiement G, Wessinger SJ, Waltman AC, Harris WH. Low-dose warfarin versus external pneumatic compression for prophylaxis against venous thromboembolism following total hip replacement. J Arthroplasty. 1987;2:23–6.
Amstutz HC, Friscia DA, Dorey F, Carney BT. Warfarin prophylaxis to prevent mortality from pulmonary embolism after total hip replacement. J Bone Joint Surg. 1989;71A:321–6.
Dale C, Gallus A, Wycherley A, Langlois S, Howie D. Prevention of venous thrombosis with minidose warfarin after joint replacement. BMJ. 1991;303:224.
Fordyce MJF, Baker AS, Staddon GE. Efficacy of fixed minidose warfarin prophylaxis in total hip replacement. BMJ. 1991;303:219–20.
Muhe E. Intermittent sequential high-pressure compression of the leg. A new method of preventing deep vein thrombosis. Am J Surg. 1984;147:781–5.
Blackshear WM, Prescott C, LePain F, Benoit S, Dickstein R, Seifert KB. Influence of sequential pneumatic compression on postoperative venous function. J Vasc Surg. 1987;5:432–6.
Guyton DP, Khayat A, Husni EA, Schreiber H. Elevated levels of 6-keto-prostaglandin-F1A from a lower extremity during external pneumatic compression. Surg Gynecol Obstet. 1988;166:338–42.
Tarnay TJ, Rohr PR, Davidson AG, Stevenson MM, Byars EF, Hopkins GR. Pneumatic calf compression, fibrinolysis, and the prevention of deep venous thrombosis. Surgery. 1980;88:489–96.
Caprini JA, Chucker JL, Zuckerman L, Vagher JP, Franck CA, Cullen JE. Thrombosis prophylaxis using external compression. Surg Gynecol Obstet. 1983;156:599–604.
Nicolaides AN, Miles C, Hoare M, Jury P, Helmis E, Venniker R. Intermittent sequential pneumatic compression of the legs and thromboembolism-deterrent stockings in the prevention of postoperative deep venous thrombosis. Surgery. 1983;94:21–5.
Nicolaides AN, Fernandes JF, Pollock AV. Intermittent sequential pneumatic compression of the legs in prevention of venous stasis and postoperative deep venous thrombosis. Surgery. 1980;87:69–76.
Salzman EW. Physical methods for prevention of venous thromboembolism. Surgery. 1977;81:123–4.
Hartman JT, Pugh JL, Smith RD, Robertson WW, Yost RP, Janssen HF. Cyclic sequential compression of the lower limb in prevention of deep venous thrombosis. J Bone Joint Surg. 1982;64A:1059–62.
Hull RD, Raskob GE, Gent M, et al. Effectiveness of intermittent pneumatic leg compression for preventing deep vein thrombosis after total hip replacement. JAMA. 1990;263:2313–7.
Harris WH, Raines J, Athanasoulis C, Waltman AC, Salzman EW. External pneumatic compression versus warfarin in reducing thrombosis in high-risk hip patients. In: Madden JL, Hume M (eds). Venous thromboembolism: prevention and treatment. New York: Appleton-Century-Crofts, 1976;51–60.
Harris WH. (Letter). J Bone Joint Surg. 1985;67A:983.
Landefeld CS, McGuire E, Cohen AM. Clinical findings associated with acute proximal deep vein thrombosis: a basis for quantifying clinical judgement. Am J Med. 1990;88:382–8.
Hirsh J, Hull RD, Raskob GE. Clinical features and diagnosis of venous thrombosis. J Am Coll Cardiol. 1986;8:114B-27B.
Hoellerich VL, Wigton RS. Diagnosing pulmonary embolism using clinical findings. Arch Intern Med. 1986;146:1699–704.
Hull R, Hirsh J, Sackett DL, et al. Replacement of venography in suspected venous thrombosis by impedance plethysmography and 125I-fibrinogen leg scanning: a less invasive approach. Ann Intern Med. 1981;94:12–5.
Paiement G, Wessinger SJ, Waltman AC, Harris WH. Surveillance of deep vein thrombosis in asymptomatic total hip replacement patients. Impedance phlebography and fibrinogen scanning versus roentgenographic phlebography. Am J Surg. 1988;155:400–4.
Cruickshank MK, Levine MN, Hirsh J, et al. An evaluation of impedance plethysmography and 125I-fibrinogen leg scanning in patients following hip surgery. Thromb Haemost. 1989;62:830–4.
Harris WH, McKusick K, Athanasoulis CA, Waltman AC, Strauss HW. Detection of pulmonary embolis after total hip replacement using serial C1502 pulmonary scans. J Bone Joint Surg. 1984;66A:1388–93.
Bell WR, Simon TL. Current status of pulmonary thromboembolic disease: pathophysiology, diagnosis, prevention, and treatment. Am Heart J. 1982;103:239–62.
Hull RD, Hirsh J, Sackett DL, Stoddart GL. Cost—effectiveness of primary and secondary prevention of fatal pulmonary embolism in high-risk surgical patients. Can Med Assoc J. 1982;127:990–5.
Oster G, Tuden RL, Colditz GA. A cost—effectiveness analysis of prophylaxis against deep-vein thrombosis in major orthopedic surgery. JAMA. 1987;257:203–8.
Paiement GD, Wessinger SJ, Harris WH. Survey of prophylaxis against venous thromboembolism in adults undergoing hip surgery. Clin Orthop. 1987;223:188–93.
Francis CW, Pellegrini VD, Marder VJ, et al. Comparison of warfarin and external pneumatic compression in prevention of venous thrombosis after total hip replacement. JAMA. 1992;267:2911–5.
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Potyk, D.K., Tabbarah, H.J. The pathogenesis and prevention of thromboembolic complications in patients undergoing total hip replacement. J Gen Intern Med 8, 213–219 (1993). https://doi.org/10.1007/BF02599270
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DOI: https://doi.org/10.1007/BF02599270