Abstract
Objective: To compare the efficacies and cost-effectivenesses of four strategies for the management of suspected pedal osteomyelitis in the setting of vascular impairment: 1) therapeutic trial of short-term antibiotics for presumed cellulitis without osteomyelitis (short); 2) technetium bone scanning followed by either short-term therapy if negative or either a biopsy or aggressive long-term intravenous therapy if positive (scan); 3) bone biopsy followed by long-term intravenous therapy if positive or short-term therapy if negative (biopsy); and 4) immediate long-term intravenous antibiotics for presumed osteomyelitis (long).
Design: Decision analysis and cost-effectiveness analysis with sensitivity analyses. The main outcomes states are amputation and the resource expenditures associated with bone scans, biopsies, and therapies.
Data sources: The authors obtained estimates of test accuracy from literature review and summarized them using newly developed meta-analytic techniques.
Main results: The optimal decision depends heavily on the estimated probability of osteomyelitis at presentation. At very low probabilities, the short-term strategy is preferred. When the probability of osteomyelitis is from 2% to 8%, the lowest amputation rate occurs when one does a diagnostic scan. From 8% to 50%, the best outcomes follow biopsy. At probabilities higher than 50%, the preferred strategy is long-term antibiotics. However, the differences in outcomes are quite small even when osteomyelitis is a virtual certainty.
Conclusions: Over the whole range of prior probabilities, the short-term strategy is the least expensive. At very low probabilities, it dominates the other strategies. When the likelihood of osteomyelitis is higher (10–20%), scanning results in outcomes and cost-effectiveness ratios comparable to those of immediate biopsy and is less invasive. When the probability of osteomyelitis is 50%, biopsy is quite cost-effective compared with all the other strategies (cost-effectiveness ratio = $15,502 per amputation averted) and is preferred to the scan strategy. When the confidence that a patient has osteomyelitis is very high (>90% probability), the improved outcomes associated with long-term antibiotics are achieved with little additional expense and with favorable cost-effectiveness ratios compared with those of the other strategies.
Similar content being viewed by others
References
Bamberger DM, Daus GP, Gerding DN. Osteomyelitis in the feet of diabetic patients: long-term results, prognostic factors and the role of antimicrobial and surgical therapy. Am J Med. 1987;83:653–60.
Dillon RS. Successful treatment of osteomyelitis and soft tissue infections in ischemic diabetic legs by local antibiotic injections and the end-diastolic pneumatic compression boot. Ann Surg. 1986;204:643–9.
Apelqvist J, Castenfors J, Larsson J, Stenstrom A, Agardh CD. Wound classification is more important than site of ulceration in the outcome of diabetic foot ulcers. Diabetic Med. 1989;6:526–30.
Littenberg B, Mushlin AI, and the Diagnostic Technology Assessment Consortium. Bone scans in the diagnosis of osteomyelitis: a meta-analysis of test performance. J Gen Intern Med. 1992;7:158–64.
Ambrose GB, Alpert M, Neer CS. Vertebral osteomyelitis: a diagnostic problem. JAMA. 1966;197:101–4.
Caprioli R, Testa J, Cournoyer RW, Esposito FJ. Prompt diagnosis of suspected osteomyelitis by utilizing percutaneous bone culture. J Foot Surg. 1986;25:263–9.
Cotty PH, Fouquet B, Pleskof L, et al. Vertebral osteomyelitis: value of percutaneous biopsy. J Neuroradiol. 1988;15:13–21.
Gladstein MO, Grantham SA. Closed skeletal biopsy. Clin Orthop. 1974;103:75–9.
Joshi KB, Brinker RA. Fine needle diagnosis in lumbar osteomyelitis. Skeletal Radiol. 1983;10:173–5.
Sugarman B, Hawes S, Musher DM, Klima M, Young FJ, Pircher F. Osteomyelitis beneath pressure sores. Arch Intern Med. 1983;143:683–8.
Thornhill-Joynes M, Gonzales F, Stewart CA, et al. Osteomyelitis associated with pressure ulcers. Arch Phys Med Rehabil. 1986;67:214–8.
Littenberg B, Moses LE. Estimating diagnostic accuracy from multiple conflicting reports: a new meta-analytic method. Med Decis Making. 1993;13:313–21.
Author information
Authors and Affiliations
Consortia
Additional information
Supported by a grant from the John A. Hartford Foundation. Dr. Littenberg is an American College of Physicians George Morris Piersol Teaching and Research Scholar.
Reprints are not available.
The Consortium included: Dartmouth-Hitchcock Medical Center: W. Blair Brooks, MD, Terry Hurlbut HI, MD, Benjamin Littenberg, MD, Andre Midgette, MD, MPH, David Smith, MD, Harold C. Sox, Jr., MD, and Carole Toselli, MD; Massachusetts General Hospital: Albert Mulley, Jr., MD; Stanford University: Lincoln E. Moses, PhD; University of Pennsylvania: Bruce Kinosian, MD, and J. Sanford Schwartz, MD; University of Rochester Medical Center: Daniel Kido, MD, Alvin I. Mushlin, MD, and Charles E. Phelps, PhD; and University of Washington: Richard Hoffman, MD, Dan Kent, MD, and Eric Larson, MD.
Rights and permissions
About this article
Cite this article
Mushlin, A.I., Littenberg, B. & the Diagnostic Technology Assessment Consortium. Diagnosing pedal osteomyelitis. J Gen Intern Med 9, 1–7 (1994). https://doi.org/10.1007/BF02599133
Issue Date:
DOI: https://doi.org/10.1007/BF02599133