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The importance of measuring Fc+ (killer) cells in insulin-dependent (type 1) diabetes

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Summary

The measurement of Fc+ (killer or K) cells in insulin dependent (Type 1) diabetes may be of considerable value in monitoring activity of immune disturbance. K cells were investigated in Type 1 diabetics, their relatives and normal controls employing two methods based upon different principles. A close positive linear correlation was observed between the two methods in all subjects. Type 1 diabetic patients showed an increased level of K-cells with both techniques. In addition there was a good correlation between raised levels of K-cells and the occurrence of organ specific autoantibodies.

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References

  1. Li Shen P. M., Lydyard P., Penfold P., Roitt I. M.: Evidence for antibody-dependent cell-mediated cytotoxicity by T cells bearing receptors for IgG — Clin. Exp. Immunol.35, 276, 1979.

    Google Scholar 

  2. Natvig J. B., Froland S. S.: Detection of a third lymphocyte-like cell type by rosette formation with erythrocytes sensitised by various anti-Rh antibodies — Scand. J. Immunol.5 (Suppl. 5), 83, 1976.

    Article  PubMed  Google Scholar 

  3. Pozzilli P., Sensi M., Gorsuch A. N., Bottazzo G. F., Cudworth A. G.: Evidence for raised K cell levels in Type 1 diabetes — Lancet2, 173, 1979.

    Article  PubMed  CAS  Google Scholar 

  4. West W. H., Payne S. M., Weese J. L., Herberman R. B.: Human T lymphocyte subpopulations: correlation between E-rosette forming affinity and expression of the Fc receptor — J. Immunol.119, 548, 1977.

    PubMed  CAS  Google Scholar 

  5. West W. H., Boozer B., Herberman R. B.: Low affinity E-rosette formation by the human K cells — J. Immunol.120, 90, 1978.

    PubMed  CAS  Google Scholar 

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Authors and Affiliations

  1. Cattedra di Endocrinologia dell’Università di Roma, Italy

    Paolo Pozzilli

  2. Medical Unit, Department of Diabetes, St. Bartholomew’s Hospital, West Smithfield, EC1A 7BE, London, Great Britain

    Paolo Pozzilli, Maurizio Sensi, Betty Dean, Andrew Gorsuch & Andrew Cudworth

Authors
  1. Paolo Pozzilli
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  2. Maurizio Sensi
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  3. Betty Dean
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  4. Andrew Gorsuch
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  5. Andrew Cudworth
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Pozzilli, P., Sensi, M., Dean, B. et al. The importance of measuring Fc+ (killer) cells in insulin-dependent (type 1) diabetes. Acta diabet. lat 17, 119–122 (1980). https://doi.org/10.1007/BF02580993

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  • DOI: https://doi.org/10.1007/BF02580993

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