Summary
After the outbreak of an endemy of HCV infections in the paediatric haematology and oncology wards, epidemiological analysis was performed for cancer children, health-care workers and controls. The study included a total of 639 persons, divided into four groups. The results were as follows: 1) The number of infected paediatric cancer patients was 100/237 (42.4%). 2) Of the 44 health-care workers in the haemato-oncology ward none was infected with HCV. 3) In the other parts of the hospital, five out of 258 (1.9%) permanently employed staff at risk of occupational exposure to blood and other body fluids were infected with HCV; however, the infection rate included only nurses (5/125, i.e. 4%). 4) One hundred adults consecutively tested for anti-HCV antibodies before a planned surgical procedure were not infected with HCV (control group). This study shows that complex nonspecific prophylaxis and full awareness in everyday work has helped to prevent transmission of HCV from highly contagious patients to medical personnel, particularly to nurses who have the highest occupational risk.
References
Arico, M., Maggiore, G., Silini, E., Bono, F., Vigano, C., Cerino, A., Mondelli, M. U.: Hepatitis C virus infection in children treated for acute lymphoblastic leukemia. Blood 84 (1994) 2919–2922.
Monteleone, P. M., Andrzejewski, C., Kelleher, J. F.: Prevalence of antibodies to hepatitis C virus in transfused children with cancer. Am. J. Pediatr., Hematol. Oncol. 16 (1994) 309–313.
Struve, J., Aronsson, B., Frenning, B., Forscgren, M., Weiland, O.: Prevalence of antibodies against hepatitis C virus infection among health care workers in Stockholm. Scand. J. Gastroenterol. 29 (1994) 360–362.
Allander, T., Gruber, A., Naghavi, M., Beyene, A., Soderstrom, T., Bjorkholm, M., Grillner, L., Persson, M. A. A.: Frequent patient-to-patient transmission of hepatitis C virus in a haematology ward. Lancet 345 (1995) 603–607.
Goets, A. M., Ndimbie, O. K., Wagener, M. M., Muder, R. R.: Prevalence of hepatitis C infection in health care workers affiliated with a liver transplant center. Transplantation 59 (1995) 990–994.
Klein, R. S., Freeman, K., Taylor, P. E., Stevens, C. E.: Occupational risk for hepatitis C virus among New York City dentists. Lancet 338 (1991) 1539–1542.
Zuckerman, J., Clewley, G., Griffiths, P., Cockroft, A.: Prevalence of hepatitis C antibodies in clinical health-care workers. Lancet 343 (1994) 1618–1620.
Thomas, D. L., Factor, S. H., Kelen, G. D., Washington, A. S., Taylor, E., Quinn, T. C.: Viral hepatitis in health care personnel at The Johns Hopkins Hospital. Arch. Intern. Med. 153 (1993) 1705–1712.
Campello, C., Majori, S., Poli, A., Pacini, P., Nicolardi, L., Pini, F.: Prevalence of HCV antibodies in health-care workers from Northern Italy. Infection 20 (1992) 224–226.
Francavilla, E., Rinaldi, R., Cattelan, A. M., Vicariotto, M., Bortolotti, F., Cadrobbi, P.: Low prevalence of antibodies to hepatitis C virus in hospital employees. Infection 20 (1992) 295.
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Styczynski, J., Koltan, S., Wysocki, M. et al. Risk of HCV infections among children with cancer and health-care workers in children's hospitals. Infection 27, 36–38 (1999). https://doi.org/10.1007/BF02565169
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DOI: https://doi.org/10.1007/BF02565169