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Comparison of renal responses to synthetic human PTH(1–34) administration in normal young and elderly male subjects

  • Clinical Investigations
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Summary

A parathyroid hormone (PTH) loading test with synthetic human PTH(1–34) was performed in 7 young and 6 elderly normal males. The elderly subjects had significantly higher mean basal levels of serum PTH than the young subjects (0.262±0.035(SE) vs 0.097±0.012 ng Eq/ml,P<0.001). When human PTH(1–34) at a dose of 100 U was administered to these subjects, the mean increases in urinary excretions of adenosine cyclic 3′, 5′-monophosphate(cAMP) and inorganic phosphorus (Pi), expressed as increases in absolute amounts per unit time, were significantly lower in the elderly subjects. (3.65±1.02 vs 7.41±1.05 μmol/h,P<0.05 for cAMP and 14.7±6.3 vs 41.8±8.6 mg/2h,P<0.05 for Pi) and an inverse correlation was found between the serum PTH levels and the increases in urinary cAMP excretion (μmol/hr; r=−0.63,P<0.05). However, when corrected for the glomerular filtration rate (GFR) and the units of PTH administered per kg body weight, the increases were not significantly different in the two groups (elderly 52.1±7.5 vs young 60.0±19.2 nmol·kg/100 ml GFR·U·h for cAMP and 0.315±0.061 vs 0.186±0.044 mg·kg/100 ml GFR·U·2 h respectively for Pi). These results indicated that the decreased response of the kidney to PTH in elderly subjects can be explained mainly by the decreased functional mass of the kidney, possibly with some contribution of down-regulation of PTH receptors owing to increase in the blood level of endogenous PTH in elderly subjects. Further investigations are needed to ascertain why there was decreased response of the kidney to PTH in elderly people.

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Authors and Affiliations

  1. Department of Medicine and Geriatrics, Osaka University Medical School, Fukushima-ku, 553, Osaka, Japan

    Shunji Imanaka, Toshio Onishi, Shigeto Morimoto, Shoshi Takamoto, Hiroshi Kohno & Yuichi Kumahara

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  1. Shunji Imanaka
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  2. Toshio Onishi
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  3. Shigeto Morimoto
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  4. Shoshi Takamoto
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  5. Hiroshi Kohno
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  6. Yuichi Kumahara
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Imanaka, S., Onishi, T., Morimoto, S. et al. Comparison of renal responses to synthetic human PTH(1–34) administration in normal young and elderly male subjects. Calcif Tissue Int 37, 357–362 (1985). https://doi.org/10.1007/BF02553701

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