Skip to main content

Advertisement

SpringerLink
Log in

TheIn Vivo, role of bone marrow fibroblast-like stromal cells

  • Editorials
  • Published:
Calcified Tissue International Aims and scope Submit manuscript

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

References

  1. Urist MR, McLean FC (1952) Osteogenic potency and new bone formation by induction in transplants to the anterior chamber of the eye. J Bone Jt Surg 34-A:443–470

    CAS  Google Scholar 

  2. Danis A (1957) Etude de l'ossification dans les greffes de moelle osseuse. Acta Med Belg 56(suppl 3):1–120

    CAS  Google Scholar 

  3. Friedenstein AJ (1973) Determine and inducible osteogenic precursor cells. In: Ciba Foundation Symposium 11 (New Series). Elsevier-Exerpta Medica-North Holland, NY, pp 169–182.

    Google Scholar 

  4. Herbertson A, Aubin JE (1995) Dexamethasone alters the subpopulation make-up of rat bone marrow stromal cell cultures. J Bone Miner Res 10:285–294

    PubMed  CAS  Google Scholar 

  5. Aubin JE, Turksen K, Heersche JNM (1993) Osteoblastic cell lineage. In: Noda M (ed) Cellular and molecular biology of bone. Academic Press, New York, pp 1–45

    Google Scholar 

  6. Lochlin RM, Williamson MC, Beresford JN, Triffitt JT, Owen ME (1995) In vitro effects of growth factors and dexamethasone on rat marrow stromal cells. Clin Orthop Rel Res 313: 27–35

    Google Scholar 

  7. Skjodt H, Russell G (1992) Bone cell biology and the regulation of bone turnover. In: Gowan M (ed) Cytokines and bone metabolism. CRC Press, Boca Raton, FL., pp 2–70

    Google Scholar 

  8. Passi-Even L, Gazit D, Bab I (1993) Ontogenesis of ultrastructural features during osteogenic differentiation in diffusion chamber cultures of marrow cells. J Bone Miner Res 8:589–595

    PubMed  CAS  Google Scholar 

  9. Iwamoto M, Shibano K, Watanabe J, Asada-Kubota M, Ogawa R, Kanamura S (1993) Culture of marrow stromal cells derived from bone marrow specimens formed at fracture site of human long bone. Bone 14:799–805

    Article  PubMed  CAS  Google Scholar 

  10. Tiedeman JJ, Connolly JF, Strates B, Lippiello L (1991) Treatment of nonunion by percutaneous injection of bone marrow and demineralized bone matrix. An experimental study in dogs. Clin Orthop Rel Res 268:294–302

    Google Scholar 

  11. Thies RS, Bauduy M, Ashton BA, Kurtzberg L, Wozney JM, Rosen V (1992) Recombinant human bone morphogenetic protein-2 induces osteoblastic differentiation in W-20-17 stromal cells. Endocrinology 130:1318–1324

    Article  PubMed  CAS  Google Scholar 

  12. Tabuchi C, Simmons DJ, Fausto A, Binderman I, Avioli LV (1989) Effect of dihydrotachysterol on bone induction in ovariectomized rats. Bone Miner 5:359–370

    Article  PubMed  CAS  Google Scholar 

  13. Goshima J, Goldberg VM, Caplan AI (1991) The origin of bone formed in composite grafts of porous calcium phosphate ceramic loaded with marrow cells. Clin Orthop Rel Res 269: 274–283

    Google Scholar 

  14. Ohgushi H, Okumura M, Tamai S, Shors EC, Caplan AI (1990) Marrow cell-induced osteogenesis in porous hydroxyapatite and tricalcium phosphate: a comparative histomorphometric study of ectopic bone formation. J Biomed Mater Res 24:1563–1570

    Article  PubMed  CAS  Google Scholar 

  15. Menton DN, Simmons DJ, Orr BV, Plurad SB (1982) A cellular investment of bone marrow. Anat Rec 203:157–164

    Article  PubMed  CAS  Google Scholar 

  16. Simmons DJ (1966) Collagen formation and endochondral ossification in estrogen-treated mice. Proc Soc Exp Biol Med 121:1165–1168

    PubMed  CAS  Google Scholar 

  17. Urist MR, Budy AM, McLean FC (1949) Endosteal bone formation in estrogen-treated mice. J Bone Jt Surg 31-A:143–162

    Google Scholar 

  18. Selye H (1932) On the stimulation of new bone formation with parathyroid extract and irradiated ergosterol. Endocrinology 16:547–558

    Article  CAS  Google Scholar 

  19. Simmons DJ (1963) Cellular changes in the bones of mice as studied with tritiated thymidine and the effects of estrogen. Clin Orthop Rel Res 26:176–189

    CAS  Google Scholar 

  20. Simmons DJ, Menton DN, Russell JE, Smith R, Walker WJ (1988) Bone cell populations and histomorphometric correlates to function. Anat Rec 222:228–236

    Article  PubMed  CAS  Google Scholar 

  21. Young RW (1962) Cell proliferation and specialization during endochondral osteogenesis in young rats. J Cell Biol 14:357–370

    Article  PubMed  CAS  Google Scholar 

  22. Tonna EA, Cronkite EP (1961) Cellular response to fracture studied with tritiated thymidine. J Bone Jt Surg 43-A:352–362

    Google Scholar 

  23. Young RW (1964) Specialization of bone cells. In: Frost H (ed) Bone biodynamics. Little, Brown and Co, Boston MA, pp 117–139

    Google Scholar 

  24. Owen ME, Care J, Joyner CJ (1987) Clonal analysis in vitro of osteogenic differentiation of marrow CFU-F. J Cell Sci 87:731–738.

    PubMed  Google Scholar 

  25. Lee K, Deeds JD, Chiba S, Un-No M, Bond AT, Segre GV (1994) Parathyroid hormone induces sequential c-fos expression in bone cells in vivo: in situ localization of its receptor and c-fos messenger ribonucleic acids. Endocrinology 134: 441–450

    Article  PubMed  CAS  Google Scholar 

  26. Zhang RW, Supowit SC, Xu X, Li H, Christensen D, Lozano R, Simmons DJ (1995) Expression of selected osteogenic markers in the fibroblast-like cells of the rat marrow stroma. Calcif Tissue Int 56:283–291

    Article  PubMed  CAS  Google Scholar 

  27. Nishida S, Yamaguchi A, Tanizawa T, Endo N, Mashiba T, Uchiyama Y, Suda T, Yoshiki S, Takahashi HE Increased bone formation by intermittent parathyroid hormone administration is due to the stimulation of proliferation and differentiation of osteoprogenitor cells in bone marrow. Bone 15:717–723

  28. Urist MR, Budy AM, McLean FC (1948) Species differences in the reaction of the mammalian skeleton to estrogen. Proc Soc Exp Biol Med 68:324–326

    CAS  PubMed  Google Scholar 

  29. Takano-Yamamoto T, Rodan GA (1990) Direct effects of 17β-estradiol on trabecular bone in ovariectomized rats. Proc Natl Acad Sci USA 87:2172–2176

    Article  PubMed  CAS  Google Scholar 

  30. Kidder LS, Klein GL, Stuart CA, Lee TL, Gundberg, CM, Alcock N, Cooper CW, Simmons DJ (1990) Musculoskeletal effects of sodium fluoride during hypokinesia: putative roles of insulin and IGF-1. Bone Miner 11:305–318

    Article  PubMed  CAS  Google Scholar 

  31. Jaworski ZFG (1980) Study of cell kinetics within evolving secondary haversian systems. J Anat 131:91–102

    PubMed  CAS  Google Scholar 

  32. Tabuchi C, Simmons DJ, Fausto A, Russell JE, Binderman I, Avioli LV (1986) Bone deficit in ovariectomized rats: the functional contribution of the marrow stromal cell population and the effect of oral dihydrotachysterol treatment. J Clin Invest 78:637–642

    Article  PubMed  CAS  Google Scholar 

  33. Kahn AJ, Gibbons R, Perkins S, Gazit D (1995) Age-related bone loss. A hypothesis and initial assessment in mice. Clin Orthop Rel Res 313:69–75

    Google Scholar 

  34. Simmons DJ, Kidder, Thomas M (1990) Effect of cortisone on cells at the bone-marrow interface. Calcif Tissue Int 46:327–332

    Article  PubMed  CAS  Google Scholar 

  35. Zhang R, Supowit SC, Klein GL, Lu Z, Christensen MD, Lozano R, Simmons DJ (1995) Rat tail suspension reduces messenger RNA level for growth factors and osteopontin and decreases the osteoblastic differentiation of bone marrow stromal cells. J Bone Miner Res 10:415–423

    Article  PubMed  CAS  Google Scholar 

  36. Simmons DJ, Zhang RW, Lu Z, Randall D, Mendonsa R, Lozano R (1994) Stromal cell regulation of bone formation and resorption. In: Davidovitch Z (ed) The biological mechanisms of tooth eruption, resorption and replacement by implants. Harvard Society Advancement of Orthodontics. Boston, MA, pp 73–84

    Google Scholar 

  37. Simmons DJ (1992) Circadian aspects of bone biology. In: Hall BK (ed) Bone v6, bone growth-A. CRC Press, Boca Raton FL, pp 91–128

    Google Scholar 

  38. Welch RD, Waldron MJ, Hulse DA, Johnston CE II, Hargis BM (1992) Intraosseous infusion using the osteoport implant in the caprine tibia. J Orthop Res 10:789–799

    Article  PubMed  CAS  Google Scholar 

  39. Simmons DJ, Lesker PA, Ellsasser JC (1975) Survival of osteocompetent marrow cells in vitro and the effect of PHA-stimulation in osteoinduction in composite bone grafts. Proc Soc Exp Biol Med 148:986–989

    PubMed  CAS  Google Scholar 

  40. Benyahu D, Fried A, Zipori D, Wientroub S (1991) Subpopulations of marrow stromal cells share a variety of osteoblastic markers. Calcif Tissue Int 49:202–207

    Article  Google Scholar 

  41. Long MW, Robinson JA, Ashcraft EA, Mann KG (1995) Regulation of human bone marrow-derived osteoprogenitor cells by osteogenic growth factors. J Clin Invest 95:881–887

    Article  PubMed  CAS  Google Scholar 

  42. Gronthos S, Graves SE, Ohta S, Simmons PJ (1994) The STRO-1+ fraction of adult human bone marrow contains the osteogenic precursors. Blood 84:4164–4173

    PubMed  CAS  Google Scholar 

  43. Gronthos S, Simmons PJ (1995) The growth factor requirements of STRO-1-positive human bone marrow stromal precursors under serum-deprived conditions in vitro. Blood 85: 929–940

    PubMed  CAS  Google Scholar 

  44. Kidder LS, Klein GL, Simmons DJ, Rubin NJ (1990) The effects of aluminum on an osteoprogenitor cell population. J Bone Miner Res 5(suppl 2):S150

    Google Scholar 

  45. Zhang RW, Simmons DJ, Crowther FS, Mohan S, Baylink DJ (1991) Contribution of marrow stromal cells to the regulation of osteoblast proliferation in rats: evidence for the involvement of insulin-like growth factors. Bone Miner 13:201–215

    Article  PubMed  CAS  Google Scholar 

  46. Bennett JH, Joyner CJ, Triffitt JT, Owen ME (1991) Adipocytic cells cultured from marrow have osteogenic potential. J Cell Sci 99:131–139

    PubMed  Google Scholar 

  47. Beresford JN, Bennett JH, Devlin C, Leboy PS, Owen ME (1992) Evidence for an inverse relationship between the differentiation of adipocytic and osteogenic cells in rat marrow stromal cell cultures. J Cell Sci 102:341–351

    PubMed  CAS  Google Scholar 

  48. Katoh M, Kitamura K, Kitagawa H (1995) Induction of bone-resorbing activity by mouse stromal cell line. MC3T3-G2/PA6. Bone 16:97–102

    Article  PubMed  CAS  Google Scholar 

  49. Guba SC, Sartor CI, Gottschalk LR, Ye-Hu J, Mulligan T, Emerson SG (1992) Bone marrow stromal fibroblasts secrete interleukin-6 and granulocyte-macrophage colony-stimulating factor in the absence of inflammatory stimulation: demonstration by serum-free bioassay, enzyme-linked immunosorbent assay, and reverse transcriptase polymerase chain reaction. Blood 80:1190–1198

    PubMed  CAS  Google Scholar 

  50. Bellido T, Girasole G, Passeri G, Yu X-P, Mocharla H, Jilka RL, Notides A, Manolagas SC (1993) Demonstration of estrogen and vitamin D receptors in bone marrow-derived stromal cells: up-regulation of the estrogen receptor by 1,25-dihydroxyvitamin-D3. Endocrinology 133:553–562

    Article  PubMed  CAS  Google Scholar 

  51. Takahashi N, Udagawa N, Askatsu T, Tanaka H, Isogai Y, Suda T (1991) Deficiency of osteoclasts in osteopetrotic mice is due to a defect in the local environment provided by osteoblastic cells. Endocrinology 128:1792–1796

    Article  PubMed  CAS  Google Scholar 

  52. Bryan P, Galvin RJS (1994) Establishment and characterization of porcine osteoclast differentiation and bone resorption assays using spleen-derived osteoclast precursor cells. J Bone Miner Res 9(suppl 1):247

    Google Scholar 

  53. Shuto T, Jimi E, Kukita T, Hirata M, Koga T (1994) Granulocyte-macrophage colony-stimulating factor suppresses lipopolysaccharide-induced osteoclast-like cell formation in mouse bone marrow cultures. Endocrinology 134:831–837

    Article  PubMed  CAS  Google Scholar 

  54. Wijngaert FPv, Tas MC, Meer JMv, Burger EH (1987) Growth of osteoclast precursor-like cells from whole mouse bone marrow: inhibitory effect of CSF-1. Bone Miner 3:97–110

    PubMed  Google Scholar 

  55. Turksen K, Aubin JE (1991) Positive and negative immunos-election for enrichment of two classes of osteoprogenitor cells. J Cell Biol 114:373–384

    Article  PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Orthopaedic Surgery and Rehabilitation, University of Texas Medical Branch, 77555, Galveston, Texas

    D. J. Simmons

Authors
  1. D. J. Simmons
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Simmons, D.J. TheIn Vivo, role of bone marrow fibroblast-like stromal cells. Calcif Tissue Int 58, 129–132 (1996). https://doi.org/10.1007/BF02526876

Download citation

  • Received:

  • Accepted:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF02526876

Search

Navigation