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New method for the analysis of multiple positron emission tomography dynamic datasets: an example applied to the estimation of the cerebral metabolic rate of oxygen

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Abstract

Positron emission tomography (PET) provides the ability to extract useful quantitative information not available through other radiological techniques. In certain studies, the physiological parameters of interest cannot be determined from the data obtained from a single PET experiment alone. In this case, multiple experiments are required. At present, the methods used to analyse measurements acquired from multiple experiments often involve considering them separately during the modelling procedures. These methods of analysis may cause errors to be propagated through successive modelling procedures and do not fully utilise the information content provided by the PET measurements. A new method is presented, based on linear least squares for the analysis of PET dynamic data acquired from multiple experiments. This method simultaneously considers the complete set of measurements obtained and provides reliable parameter estimates. The efficient use of the information content provided by multiple experiments is considered and the propagation of errors is discussed. To facilitate our discussion, we apply this new method to the estimation of the cerebral metabolic rate of oxygen and the parameters of the oxygen utilisation model as a practical example. The results demonstrate a significant improvement in the reliability and estimation accuracy of the estimates for this new method. Furthermore, this method reduced the likelihood of errors being propagated. Therefore, the proposed method is suitable for the analysis of multiple PET dynamic datasets.

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References

  • Carson, R., Huang, S. andPhelps, M. (1981): ‘BLD—a software system for physiological data handling and model analysis’ in ‘IEEE Computer Society’, Proceedings of the Fifth Annual Symposium onComputer Applications in Medical Care, pp. 562–565

  • Chen, K., Huang, S. andYu, D. (1991): ‘The effects of measurement errors in the plasma radioactivity curve on parameter estimation in positron emission tomography’,J. Phys. Med. Biol.,36, pp. 1183–1200

    Article  Google Scholar 

  • Eichling, J., Raichle, M., Grubb, R. J. andTer-Pogossian, M. (1974): ‘Evidence of the limitations of water as a freely diffusible tracer in brain of the rhesus monkey’,Circ. Res.,35, pp. 358–364

    Google Scholar 

  • Feng, D., Wang, Z. andHuang, S. (1993): ‘A study on statistically reliable and computationally efficient algorithms for generating local cerebral blood flow parametric images with positron emission tomography’,IEEE Trans. Med. Imaging,12, pp. 182–188

    Article  Google Scholar 

  • Feng, D., Ho, D. K. C., Wu, L., Wang, J., Liu, R. andYeh, S. (1995): ‘An evaluation of the algorithms for determining local cerebral metabolic rates of glucose using positron emission tomography dynamic data’,IEEE Trans. Med. Imaging,14, pp. 697–710

    Article  Google Scholar 

  • Feng, D., Huang, S., Wang, Z. andHo, D. (1996): ‘An unbiased parametric imaging algorithm for non-uniformly sampled biomedical system parameter estimation’,IEEE Trans. Med. Imaging,43, (3), pp. 319–327

    Google Scholar 

  • Frackowiak, R., Lenzi, G., Jones, T. andHeather, D. (1980): ‘Quantitative measurement of regional cerebral blood flow and oxygen metabolism in man using15O and positron emission tomography: theory, procedure, and normal values’,J. Comput. Assist. Tomogr.,4, pp. 727–736

    Google Scholar 

  • Grubb, R. J., Raichle, M., Higgins, C. andEichling, J. (1978): ‘Measurement of regional cerebral blood volume by emission tomography’,Ann. Neurol.,4, pp. 322–328

    Article  Google Scholar 

  • Herscovitch, P., Markham, J. andRaichle, M. (1983a): ‘Brain blood flow measured with intravenous H2 15O. I: theory and error analysis’,J. Nucl. Med.,24, pp. 782–789

    Google Scholar 

  • Herscovitch, P. andRaichle, M. (1983b): ‘Effect of tissue heterogeneity on the measurement of cerebral blood flow with the equilibrium C15O2 inhalation technique’,J. Cerebral Blood Flow Metabolism,3, pp. 407–415

    Google Scholar 

  • Ho, D. andFeng, D. (1996): ‘Rapid estimation algorithms for the construction of cerebral blood flow and oxygen utilisation images with oxygen-15 and dynamic positron emission tomography’ submitted toComput. Meth. Prog. Biomed.

  • Huang, S., Carson, R. andPhelps, M. (1983): ‘A tomographic technique for the simultaneous determination of LCBF and metabolic rate of oxygen with oxygen-15’,J. Cerebral Blood Flow Metabolism,3, (Supplement 1), pp. 517–518

    Google Scholar 

  • Huang, S., Feng, D. andPhelps, M. (1986): ‘Model dependency and estimation reliability in measurement of cerebral oxygen utilization rate with oxygen-15 and dynamic positron emission tomography’,J. Cerebral Blood Flow Metabolism,6, pp. 105–119

    Google Scholar 

  • Iida, H., Jones, T., Deiber, M., Cunningham, V. andFrackowiak, R. (1990): ‘Simultaneous measurement of CMRO2 and CBF using a slow inhalation of15O2 and dynamic PET’,J. Nucl. Med.,31, p. 760

    Google Scholar 

  • Iida, H., Jones, T. andMiura, S. (1993): ‘Modeling approach to eliminate the need to separate arterial plasma in oxygen-15 inhalation positron emission tomography’,J. Nucl. Med.,34, pp. 1333–1340

    Google Scholar 

  • Jones, T., Chester, D. andTer-Pogossian, M. (1976): ‘The continuous inhalation of oxygen-15 for assessing regional oxygen extraction in the brain of man’,Br. J. Radiol.,49, pp. 339–343

    Article  Google Scholar 

  • Kety, S. (1951): ‘The theory and application of the exchange of inert gas and the lung and tissue’,Pharmacol. Rev.,3, pp. 1–41

    Google Scholar 

  • Kety, S. (1960): ‘Measurement of local blood flow by the exchange of an inert, diffusible substance’,Meth. Med. Res.,8, pp. 228–236

    Google Scholar 

  • Mintun, M., Raichle, M., Martin, W. andHerscovitch, P. (1984): ‘Brain oxygen utilization measured with O-15 radiotracers and positron emission tomography;,J. Nucl. Med.,25, pp. 177–187

    Google Scholar 

  • O'Sullivan, F. (1993): ‘Imaging radiotracer model parameters in PET: a mixture analysis approach’IEEE Trans. Med. Imaging,12, pp. 399–412

    Article  Google Scholar 

  • Ohta, S., Meyer, E., Thompson, C. andGjedde, A. (1992): ‘Oxygen consumption of the living human brain measured after a single inhalation of positron emitting oxygen’,J. Cerebral Blood Flow Metabolism,12, pp. 179–192

    Google Scholar 

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Authors and Affiliations

  1. Department of Computer Science, The University of Sydney, Sydney, Australia

    D. Ho &  D. Feng

  2. Samaritian PET Center, Phoenix, USA

    K. Chen

Authors
  1. D. Ho
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  2. D. Feng
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  3. K. Chen
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Correspondence to D. Feng.

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Ho, D., Feng, D. & Chen, K. New method for the analysis of multiple positron emission tomography dynamic datasets: an example applied to the estimation of the cerebral metabolic rate of oxygen. Med. Biol. Eng. Comput. 36, 83–90 (1998). https://doi.org/10.1007/BF02522862

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  • DOI: https://doi.org/10.1007/BF02522862

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