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Use of OPLC to study the biological activity of organic compounds

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Summary

Solute capacity factors in pure water, logk w, determined by the new method based on Ościk's equation, are proposed as descriptors of the biological activity of some benzamides. Values of logk w determined by the new method and by parabolic extrapolation were compared with the minimum inhibitory concentration (MIC) of the compounds against six different dermatophytes, and correlations between logk w and log (1/MIC) values of the same substances were analysed. For all the dermatophytes and all the compounds very good linear correlations were obtained for retention factors determined by the method proposed in this study.

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Authors and Affiliations

  1. Department of Planar Chromatography, Faculty of Chemistry, Maria Curie-Sklodowska University, Maria Curie-Sklodowska Sq.3, 20-031, Lublin, Poland

    M. Janicka

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  1. M. Janicka
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Janicka, M. Use of OPLC to study the biological activity of organic compounds. Chromatographia 57, 395–403 (2003). https://doi.org/10.1007/BF02492414

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  • DOI: https://doi.org/10.1007/BF02492414

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